Asymptomatic cattle naturally infected with Mycobacterium bovis present exacerbated tissue pathology and bacterial dissemination

Rational discovery of novel immunodiagnostic and vaccine candidate antigens to control bovine tuberculosis (bTB) requires knowledge of disease immunopathogenesis. However, there remains a paucity of information on the Mycobacterium bovis-host immune interactions during the natural infection. Analysi...

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Bibliographic Details
Published in:PloS one 2013-01, Vol.8 (1), p.e53884-e53884
Main Authors: Menin, Álvaro, Fleith, Renata, Reck, Carolina, Marlow, Mariel, Fernandes, Paula, Pilati, Célso, Báfica, André
Format: Article
Language:English
Subjects:
Animals
Antigens
Autopsy
Bacteria
Beef cattle
Biology
Biomarkers
Blood Cell Count
Bovidae
Cattle
Deoxyribonucleic acid
Disease control
DNA
Encapsulation
Giant cells
Granuloma
Histology
Immunopathogenesis
Infection
Infections
Laboratory animals
Lesions
Leukocytes (neutrophilic)
Lungs
Lymphatic system
Medicine
Mycobacterium bovis
Mycobacterium bovis - isolation & purification
Mycobacterium bovis - pathogenicity
Mycobacterium tuberculosis
Neutrophils
Neutrophils - cytology
Neutrophils - microbiology
Pathogens
Pathology
Tuberculosis
Tuberculosis, Bovine - diagnosis
Tuberculosis, Bovine - microbiology
Tuberculosis, Bovine - physiopathology
Vaccines
Veterinary Science
Viability
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Summary:Rational discovery of novel immunodiagnostic and vaccine candidate antigens to control bovine tuberculosis (bTB) requires knowledge of disease immunopathogenesis. However, there remains a paucity of information on the Mycobacterium bovis-host immune interactions during the natural infection. Analysis of 247 naturally PPD+ M. bovis-infected cattle revealed that 92% (n = 228) of these animals were found to display no clinical signs, but presented severe as well as disseminated bTB-lesions at post-mortem examination. Moreover, dissemination of bTB-lesions positively correlated with both pathology severity score (Spearman r = 0.48; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0053884