RNA virus replication complexes

  In picornavirus-infected cells, viral RNA replication occurs on the cytoplasmic surfaces of double-membrane vesicles derived from the endoplasmic reticulum (ER) [3]. In the RdRp from the foot-and-mouth disease virus, uridylated VPg occupies a site similar to the typical RNA primer in the active si...

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Bibliographic Details
Published in:PLoS pathogens 2010-07, Vol.6 (7), p.e1000943-e1000943
Main Authors: Tao, Yizhi Jane, Ye, Qiaozhen
Format: Article
Language:English
Subjects:
Biochemistry/Macromolecular Assemblies and Machines
Enzymes
Genetic aspects
Genetic transcription
Genome, Viral - genetics
Microbiology
Pearls
Physiological aspects
Polymerase chain reaction
Proteins
Ribonucleic acid
RNA
RNA viruses
RNA Viruses - physiology
RNA, Viral - biosynthesis
Structure
Virology/Viral and Gene Regulation
Virology/Virion Structure, Assembly, and Egress
Virus Replication
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Summary:  In picornavirus-infected cells, viral RNA replication occurs on the cytoplasmic surfaces of double-membrane vesicles derived from the endoplasmic reticulum (ER) [3]. In the RdRp from the foot-and-mouth disease virus, uridylated VPg occupies a site similar to the typical RNA primer in the active site canyon, with the key residue Tyr3 and its associated uridylate (UMP) projected into the active site [7]. dsRNA Viruses Replicate and Transcribe Their Genomes in Intact Core Particles Genome replication by dsRNA viruses occurs in subviral particles.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1000943