Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery?

As is apparent in many fields of science and medicine, the new biology, and particularly new high-throughput genetic sequencing and transcriptomic and epigenetic technologies, are radically altering our understanding and views of science. In this article, we make the case that while mostly ignored t...

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Bibliographic Details
Published in:PLoS pathogens 2011-12, Vol.7 (12), p.e1002344-e1002344
Main Authors: Poland, Gregory A, Kennedy, Richard B, Ovsyannikova, Inna G
Format: Article
Language:English
Subjects:
Animals
Biology
Cancer
Cancer Vaccines
Candidates
Communicable diseases
Drug Design
Epigenetics
Health aspects
Humans
Kinases
Lymphocytes
Measles
Opinion
Peptides
Prevention
Public health
Science
Tropical diseases
Vaccines
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Summary:As is apparent in many fields of science and medicine, the new biology, and particularly new high-throughput genetic sequencing and transcriptomic and epigenetic technologies, are radically altering our understanding and views of science. In this article, we make the case that while mostly ignored thus far in the vaccine field, these changes will revolutionize vaccinology from development to manufacture to administration. Such advances will address a current major barrier in vaccinology-that of empiric vaccine discovery and development, and the subsequent low yield of viable vaccine candidates, particularly for hyper-variable viruses. While our laboratory's data and thinking (and hence also for this paper) has been directed toward viruses and viral vaccines, generalization to other pathogens and disease entities (i.e., anti-cancer vaccines) may be appropriate.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1002344