Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh

Bats are reservoirs for a wide range of zoonotic agents including lyssa-, henipah-, SARS-like corona-, Marburg-, Ebola-, and astroviruses. In an effort to survey for the presence of other infectious agents, known and unknown, we screened sera from 16 Pteropus giganteus bats from Faridpur, Bangladesh...

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Bibliographic Details
Published in:PLoS pathogens 2010-07, Vol.6 (7), p.e1000972-e1000972
Main Authors: Epstein, Jonathan H, Quan, Phenix-Lan, Briese, Thomas, Street, Craig, Jabado, Omar, Conlan, Sean, Ali Khan, Shahneaz, Verdugo, Dawn, Hossain, M Jahangir, Hutchison, Stephen K, Egholm, Michael, Luby, Stephen P, Daszak, Peter, Lipkin, W Ian
Format: Article
Language:English
Subjects:
Animals
Bangladesh
Bats
Birds
Care and treatment
Chiroptera - virology
Computational Biology/Comparative Sequence Analysis
Computational Biology/Molecular Genetics
Computational Biology/Sequence Motif Analysis
Diseases
DNA sequencing
DNA, Viral - analysis
Ecology/Evolutionary Ecology
Filovirus
Flaviviridae
Flaviviridae - classification
Flaviviridae - genetics
Flavivirus
GB virus
GB virus A - genetics
GB virus C - genetics
Genetic aspects
Genetics and Genomics/Bioinformatics
Genetics and Genomics/Comparative Genomics
Genetics and Genomics/Genetics of Disease
Genetics and Genomics/Microbial Evolution and Genomics
Hepatitis
Hepatitis, Viral
Infectious Diseases/Viral Infections
Methods
Mortality
Nucleotide sequencing
Pathology/Clinical Chemistry
Phylogenetics
Phylogeny
Physiology/Gastroenterology and Hepatology
Primates
Pteropus
Public Health and Epidemiology/Infectious Diseases
Sequence Homology, Nucleic Acid
Virology/Emerging Viral Diseases
Viruses
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Summary:Bats are reservoirs for a wide range of zoonotic agents including lyssa-, henipah-, SARS-like corona-, Marburg-, Ebola-, and astroviruses. In an effort to survey for the presence of other infectious agents, known and unknown, we screened sera from 16 Pteropus giganteus bats from Faridpur, Bangladesh, using high-throughput pyrosequencing. Sequence analyses indicated the presence of a previously undescribed virus that has approximately 50% identity at the amino acid level to GB virus A and C (GBV-A and -C). Viral nucleic acid was present in 5 of 98 sera (5%) from a single colony of free-ranging bats. Infection was not associated with evidence of hepatitis or hepatic dysfunction. Phylogenetic analysis indicates that this first GBV-like flavivirus reported in bats constitutes a distinct species within the Flaviviridae family and is ancestral to the GBV-A and -C virus clades.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1000972