Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases

Introduction Malassezia is a monophyletic genus of fungi found on the skin of 7 billion humans and associated with a variety of conditions, including dandruff, atopic eczema (AE)/dermatitis, pityriasis versicolor, seborrheic dermatitis, and folliculitis ([1], [2]; Figure 1). [...]these agents also i...

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Bibliographic Details
Published in:PLoS pathogens 2012-06, Vol.8 (6), p.e1002701-e1002701
Main Authors: Saunders, Charles W, Scheynius, Annika, Heitman, Joseph
Format: Article
Language:English
Subjects:
Animals
Biology
Copper
Dermatomycoses - microbiology
Development and progression
Eczema
Eczema - microbiology
Fatty acids
Fungi
Genomes
Health aspects
Host-Parasite Interactions - physiology
Humans
Lipids
Malassezia - pathogenicity
Malassezia - physiology
Mortality
Pearls
Pheromones
Phylogeny
Physiological aspects
Scalp Dermatoses - microbiology
Skin diseases
Virulence (Microbiology)
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Summary:Introduction Malassezia is a monophyletic genus of fungi found on the skin of 7 billion humans and associated with a variety of conditions, including dandruff, atopic eczema (AE)/dermatitis, pityriasis versicolor, seborrheic dermatitis, and folliculitis ([1], [2]; Figure 1). [...]these agents also inhibit fungal calcineurin, and exhibit anti-fungal activity that has been well documented for Malassezia species [35]. [...]the efficacy of these topical agents may stem from a dual action to suppress host immune response and concomitantly inhibit growth of the fungus provoking host immune responses.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1002701