Genital tract sequestration of SIV following acute infection

We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between...

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Bibliographic Details
Published in:PLoS pathogens 2011-02, Vol.7 (2), p.e1001293-e1001293
Main Authors: Whitney, James B, Hraber, Peter T, Luedemann, Corinne, Giorgi, Elena E, Daniels, Marcus G, Bhattacharya, Tanmoy, Rao, Srinivas S, Mascola, John R, Nabel, Gary J, Korber, Bette T, Letvin, Norman L
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Animals
Antiretroviral drugs
BASIC BIOLOGICAL SCIENCES
blood
blood plasma
Causes of
Diagnosis
DNA, Viral - genetics
Drug resistance
Gene Flow
Gene Products, env - genetics
Genital diseases, Male
Genitalia, Male - virology
Health aspects
HIV
Human immunodeficiency virus
Hypothesis testing
Infections
Infectious Diseases/HIV Infection and AIDS
Infectious Diseases/Sexually Transmitted Diseases
Infectious Diseases/Viral Infections
Macaca mulatta
Male
Medical research
Migration
monkeys
phylogenetic analysis
Polymerase Chain Reaction
Reproductive system
semen
Semen - virology
Simian Acquired Immunodeficiency Syndrome - blood
Simian Acquired Immunodeficiency Syndrome - prevention & control
Simian Acquired Immunodeficiency Syndrome - virology
Simian immunodeficiency virus
Simian Immunodeficiency Virus - genetics
Simian Immunodeficiency Virus - pathogenicity
SIV
Vaccination
Viral Load
viral replication
viral vaccines
Viremia - prevention & control
Virology
Virology/Animal Models of Infection
Virology/Persistence and Latency
Virology/Vaccines
Virology/Virus Evolution and Symbiosis
Virus Replication
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Description
Summary:We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1001293