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Genital tract sequestration of SIV following acute infection
We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between...
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| Published in: | PLoS pathogens 2011-02, Vol.7 (2), p.e1001293-e1001293 |
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| creator | Whitney, James B Hraber, Peter T Luedemann, Corinne Giorgi, Elena E Daniels, Marcus G Bhattacharya, Tanmoy Rao, Srinivas S Mascola, John R Nabel, Gary J Korber, Bette T Letvin, Norman L |
| description | We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves. |
| doi_str_mv | 10.1371/journal.ppat.1001293 |
| format | article |
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At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1001293</identifier><identifier>PMID: 21379569</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Animals ; Antiretroviral drugs ; BASIC BIOLOGICAL SCIENCES ; blood ; blood plasma ; Causes of ; Diagnosis ; DNA, Viral - genetics ; Drug resistance ; Gene Flow ; Gene Products, env - genetics ; Genital diseases, Male ; Genitalia, Male - virology ; Health aspects ; HIV ; Human immunodeficiency virus ; Hypothesis testing ; Infections ; Infectious Diseases/HIV Infection and AIDS ; Infectious Diseases/Sexually Transmitted Diseases ; Infectious Diseases/Viral Infections ; Macaca mulatta ; Male ; Medical research ; Migration ; monkeys ; phylogenetic analysis ; Polymerase Chain Reaction ; Reproductive system ; semen ; Semen - virology ; Simian Acquired Immunodeficiency Syndrome - blood ; Simian Acquired Immunodeficiency Syndrome - prevention & control ; Simian Acquired Immunodeficiency Syndrome - virology ; Simian immunodeficiency virus ; Simian Immunodeficiency Virus - genetics ; Simian Immunodeficiency Virus - pathogenicity ; SIV ; Vaccination ; Viral Load ; viral replication ; viral vaccines ; Viremia - prevention & control ; Virology ; Virology/Animal Models of Infection ; Virology/Persistence and Latency ; Virology/Vaccines ; Virology/Virus Evolution and Symbiosis ; Virus Replication</subject><ispartof>PLoS pathogens, 2011-02, Vol.7 (2), p.e1001293-e1001293</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Whitney et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Whitney JB, Hraber PT, Luedemann C, Giorgi EE, Daniels MG, et al. (2011) Genital Tract Sequestration of SIV following Acute Infection. PLoS Pathog 7(2): e1001293. doi:10.1371/journal.ppat.1001293</rights><rights>Whitney et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c687t-cc55202f41ebd3dd438f6d4901603c098931620b06761623660d8f612eb150ab3</citedby><cites>FETCH-LOGICAL-c687t-cc55202f41ebd3dd438f6d4901603c098931620b06761623660d8f612eb150ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1289096641/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1289096641?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21379569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/servlets/purl/1627899$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><contributor>Emerman, Michael</contributor><creatorcontrib>Whitney, James B</creatorcontrib><creatorcontrib>Hraber, Peter T</creatorcontrib><creatorcontrib>Luedemann, Corinne</creatorcontrib><creatorcontrib>Giorgi, Elena E</creatorcontrib><creatorcontrib>Daniels, Marcus G</creatorcontrib><creatorcontrib>Bhattacharya, Tanmoy</creatorcontrib><creatorcontrib>Rao, Srinivas S</creatorcontrib><creatorcontrib>Mascola, John R</creatorcontrib><creatorcontrib>Nabel, Gary J</creatorcontrib><creatorcontrib>Korber, Bette T</creatorcontrib><creatorcontrib>Letvin, Norman L</creatorcontrib><creatorcontrib>Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)</creatorcontrib><title>Genital tract sequestration of SIV following acute infection</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Animals</subject><subject>Antiretroviral drugs</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>blood</subject><subject>blood plasma</subject><subject>Causes of</subject><subject>Diagnosis</subject><subject>DNA, Viral - genetics</subject><subject>Drug resistance</subject><subject>Gene Flow</subject><subject>Gene Products, env - genetics</subject><subject>Genital diseases, Male</subject><subject>Genitalia, Male - virology</subject><subject>Health aspects</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Hypothesis testing</subject><subject>Infections</subject><subject>Infectious Diseases/HIV Infection and AIDS</subject><subject>Infectious Diseases/Sexually Transmitted Diseases</subject><subject>Infectious Diseases/Viral Infections</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Medical research</subject><subject>Migration</subject><subject>monkeys</subject><subject>phylogenetic analysis</subject><subject>Polymerase Chain Reaction</subject><subject>Reproductive system</subject><subject>semen</subject><subject>Semen - virology</subject><subject>Simian Acquired Immunodeficiency Syndrome - blood</subject><subject>Simian Acquired Immunodeficiency Syndrome - prevention & control</subject><subject>Simian Acquired Immunodeficiency Syndrome - virology</subject><subject>Simian immunodeficiency virus</subject><subject>Simian Immunodeficiency Virus - genetics</subject><subject>Simian Immunodeficiency Virus - pathogenicity</subject><subject>SIV</subject><subject>Vaccination</subject><subject>Viral Load</subject><subject>viral replication</subject><subject>viral vaccines</subject><subject>Viremia - prevention & control</subject><subject>Virology</subject><subject>Virology/Animal Models of Infection</subject><subject>Virology/Persistence and Latency</subject><subject>Virology/Vaccines</subject><subject>Virology/Virus Evolution and Symbiosis</subject><subject>Virus Replication</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqVkk1v1DAQhiMEomXhHyCI4IA47OJvxxJCqiooK1UgUeBqObaz9SobL7HDx79n0k2rBvWCcsho_MxrvzNTFE8xWmEq8ZttHPrOtKv93uQVRggTRe8Vx5hzupRUsvu34qPiUUpbhBimWDwsjggoKC7UcfH2zHchm7bMvbG5TP7H4BPEOcSujE15sf5eNrFt46_QbUpjh-zL0DXejsDj4kFj2uSfTP9F8e3D-6-nH5fnn8_WpyfnSysqmZfWck4QaRj2taPOMVo1wjGFsEDUIlUpeBVBNRJSQECFQA4ITHyNOTI1XRTPD7r7NiY9GU8ak0ohJQS4WhTrA-Gi2ep9H3am_6OjCfoqEfuNNn0OtvW6srKmlHhFqGUUy8pxK5mTgtQOsga03k23DfXOO-s76Ec7E52fdOFSb-JPTREDCwoEXhwEYspBJxuyt5c2dh10TYNBWakRejXd0sernutdSNa3rel8HJKuOFeIMzGSL_8h7-7ARG0MmIQRxXGio6Y-IVwSMIoRUKs7KPic3wV4om8C5GcFr2cFwGT_O2_MkJJeX3z5D_bTnGUH1vYxpd43N_3FSI_7fW1Sj_utp_2Gsme3Z3NTdL3Q9C-zH_L4</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Whitney, James B</creator><creator>Hraber, Peter T</creator><creator>Luedemann, Corinne</creator><creator>Giorgi, Elena E</creator><creator>Daniels, Marcus G</creator><creator>Bhattacharya, Tanmoy</creator><creator>Rao, Srinivas S</creator><creator>Mascola, John R</creator><creator>Nabel, Gary J</creator><creator>Korber, Bette T</creator><creator>Letvin, Norman L</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>OIOZB</scope><scope>OTOTI</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110201</creationdate><title>Genital tract sequestration of SIV following acute infection</title><author>Whitney, James B ; Hraber, Peter T ; Luedemann, Corinne ; Giorgi, Elena E ; Daniels, Marcus G ; Bhattacharya, Tanmoy ; Rao, Srinivas S ; Mascola, John R ; Nabel, Gary J ; Korber, Bette T ; Letvin, Norman L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c687t-cc55202f41ebd3dd438f6d4901603c098931620b06761623660d8f612eb150ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>Animals</topic><topic>Antiretroviral drugs</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>blood</topic><topic>blood plasma</topic><topic>Causes of</topic><topic>Diagnosis</topic><topic>DNA, Viral - 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genetics</topic><topic>Simian Immunodeficiency Virus - pathogenicity</topic><topic>SIV</topic><topic>Vaccination</topic><topic>Viral Load</topic><topic>viral replication</topic><topic>viral vaccines</topic><topic>Viremia - prevention & control</topic><topic>Virology</topic><topic>Virology/Animal Models of Infection</topic><topic>Virology/Persistence and Latency</topic><topic>Virology/Vaccines</topic><topic>Virology/Virus Evolution and Symbiosis</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whitney, James B</creatorcontrib><creatorcontrib>Hraber, Peter T</creatorcontrib><creatorcontrib>Luedemann, Corinne</creatorcontrib><creatorcontrib>Giorgi, Elena E</creatorcontrib><creatorcontrib>Daniels, Marcus G</creatorcontrib><creatorcontrib>Bhattacharya, Tanmoy</creatorcontrib><creatorcontrib>Rao, Srinivas S</creatorcontrib><creatorcontrib>Mascola, John R</creatorcontrib><creatorcontrib>Nabel, Gary J</creatorcontrib><creatorcontrib>Korber, Bette T</creatorcontrib><creatorcontrib>Letvin, Norman L</creatorcontrib><creatorcontrib>Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV - Hybrid</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whitney, James B</au><au>Hraber, Peter T</au><au>Luedemann, Corinne</au><au>Giorgi, Elena E</au><au>Daniels, Marcus G</au><au>Bhattacharya, Tanmoy</au><au>Rao, Srinivas S</au><au>Mascola, John R</au><au>Nabel, Gary J</au><au>Korber, Bette T</au><au>Letvin, Norman L</au><au>Emerman, Michael</au><aucorp>Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genital tract sequestration of SIV following acute infection</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>7</volume><issue>2</issue><spage>e1001293</spage><epage>e1001293</epage><pages>e1001293-e1001293</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21379569</pmid><doi>10.1371/journal.ppat.1001293</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome AIDS Animals Antiretroviral drugs BASIC BIOLOGICAL SCIENCES blood blood plasma Causes of Diagnosis DNA, Viral - genetics Drug resistance Gene Flow Gene Products, env - genetics Genital diseases, Male Genitalia, Male - virology Health aspects HIV Human immunodeficiency virus Hypothesis testing Infections Infectious Diseases/HIV Infection and AIDS Infectious Diseases/Sexually Transmitted Diseases Infectious Diseases/Viral Infections Macaca mulatta Male Medical research Migration monkeys phylogenetic analysis Polymerase Chain Reaction Reproductive system semen Semen - virology Simian Acquired Immunodeficiency Syndrome - blood Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - pathogenicity SIV Vaccination Viral Load viral replication viral vaccines Viremia - prevention & control Virology Virology/Animal Models of Infection Virology/Persistence and Latency Virology/Vaccines Virology/Virus Evolution and Symbiosis Virus Replication |
| title | Genital tract sequestration of SIV following acute infection |
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