Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility

• Published in: PloS one 2007-06, Vol.2 (6), p.e495-e495
• Main Authors: Giusti, Betti, Gori, Anna Maria, Marcucci, Rossella, Sestini, Ilaria, Saracini, Claudia, Sticchi, Elena, Gensini, Francesca, Fatini, Cinzia, Abbate, Rosanna, Gensini, Gian Franco
• Format: Article
• Language: English
• Subjects: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - blood; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics; Adult; Aged; Aged, 80 and over; Analysis; Atrial fibrillation; Atrial Fibrillation - blood; Atrial Fibrillation - genetics; Atrial Fibrillation - pathology; Blood & organ donations; Cardiac arrhythmia; Cardiovascular Disorders/Arrhythmias, Electrophysiology, and Pacing; Case-Control Studies; Clinical trials; Colorectal cancer; Critical care; Deoxyribonucleic acid; Diabetes; Dihydrofolate reductase; Disease susceptibility; DNA; Education; Enzymes; Epigenetics; Female; Fibrillation; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Genetics and Genomics/Complex Traits; Genetics and Genomics/Genetics of Disease; Genetics and Genomics/Medical Genetics; Genotype; Genotype & phenotype; Haplotypes; Homocysteine; Humans; Hyperhomocysteinemia; Hyperhomocysteinemia - blood; Hyperhomocysteinemia - complications; Hyperhomocysteinemia - genetics; Immunoassay; Leukemia; Male; Marfan syndrome; Metabolism; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2) - blood; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Multivariate analysis; Mutation; Nitric Oxide Synthase Type III - blood; Nitric Oxide Synthase Type III - genetics; Pathogenesis; Pathology/Molecular Pathology; Patients; Polymorphism; Polymorphism, Single Nucleotide - genetics; Prognosis; Quartiles; Risk analysis; Risk Factors; Tumors; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0000495

Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF. 456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method. The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 micromol/L; p