Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility

Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF. 456 NVAF patients and 912 matched controls were genotyped b...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2007-06, Vol.2 (6), p.e495-e495
Main Authors: Giusti, Betti, Gori, Anna Maria, Marcucci, Rossella, Sestini, Ilaria, Saracini, Claudia, Sticchi, Elena, Gensini, Francesca, Fatini, Cinzia, Abbate, Rosanna, Gensini, Gian Franco
Format: Article
Language:English
Subjects:
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - blood
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics
Adult
Aged
Aged, 80 and over
Analysis
Atrial fibrillation
Atrial Fibrillation - blood
Atrial Fibrillation - genetics
Atrial Fibrillation - pathology
Blood & organ donations
Cardiac arrhythmia
Cardiovascular Disorders/Arrhythmias, Electrophysiology, and Pacing
Case-Control Studies
Clinical trials
Colorectal cancer
Critical care
Deoxyribonucleic acid
Diabetes
Dihydrofolate reductase
Disease susceptibility
DNA
Education
Enzymes
Epigenetics
Female
Fibrillation
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genetics and Genomics/Complex Traits
Genetics and Genomics/Genetics of Disease
Genetics and Genomics/Medical Genetics
Genotype
Genotype & phenotype
Haplotypes
Homocysteine
Humans
Hyperhomocysteinemia
Hyperhomocysteinemia - blood
Hyperhomocysteinemia - complications
Hyperhomocysteinemia - genetics
Immunoassay
Leukemia
Male
Marfan syndrome
Metabolism
Methylenetetrahydrofolate reductase
Methylenetetrahydrofolate Reductase (NADPH2) - blood
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Multivariate analysis
Mutation
Nitric Oxide Synthase Type III - blood
Nitric Oxide Synthase Type III - genetics
Pathogenesis
Pathology/Molecular Pathology
Patients
Polymorphism
Polymorphism, Single Nucleotide - genetics
Prognosis
Quartiles
Risk analysis
Risk Factors
Tumors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c662t-1f5bc9220a1fc5ed3cfcac3eb31c4485a69ed71b58bc9f92bc829f20e337d1f23
cites cdi_FETCH-LOGICAL-c662t-1f5bc9220a1fc5ed3cfcac3eb31c4485a69ed71b58bc9f92bc829f20e337d1f23
container_end_page e495
container_issue 6
container_start_page e495
container_title PloS one
container_volume 2
creator Giusti, Betti
Gori, Anna Maria
Marcucci, Rossella
Sestini, Ilaria
Saracini, Claudia
Sticchi, Elena
Gensini, Francesca
Fatini, Cinzia
Abbate, Rosanna
Gensini, Gian Franco
description Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF. 456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method. The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 micromol/L; p
doi_str_mv 10.1371/journal.pone.0000495
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1289145584</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A472274901</galeid><doaj_id>oai_doaj_org_article_7f1ef2da86e8426d99c708ba32e340cf</doaj_id><sourcerecordid>A472274901</sourcerecordid><originalsourceid>FETCH-LOGICAL-c662t-1f5bc9220a1fc5ed3cfcac3eb31c4485a69ed71b58bc9f92bc829f20e337d1f23</originalsourceid><addsrcrecordid>eNqNkluLEzEYhgdR3HX1H4gGhAXBdnOYHOZGKMXdLawWutXbkMkkbUo6mZ3MiP33pttRW_HC3CT58nyHvLxZ9hrBMSIcXW1C39bKj5tQmzFMKy_ok-wcFQSPGIbk6dH5LHsR4wZCSgRjz7MzxClFlLPzrF8Eb0CwYMo4XwJVV2CCcCGm4PPy9nrxAUwwp-wm3RaPjyMuGJheLYH5Mr8HK1Mb0AS_24a2Wbu4jcDVQHWtUx5YV7bOe9W5UIPYR22azpXOu273MntmlY_m1bBfZF-vPy2nt6O7-c1sOrkbacZwN0KWlrrAGCpkNTUV0VYrTUxJkM5zQRUrTMVRSUXCbIFLLXBhMTSE8ApZTC6yt4e6jQ9RDopFibAoUE6pyBMxOxBVUBvZtG6r2p0MysnHQGhXUrWd095IbpGxuFKCGZFjVhWF5lCUimBDcqhtqvVx6NaXW1NpU3et8idFT19qt5ar8F0iwZlA-2EuhwJteOhN7OTWJdmShrUJfZQcUi6ogAl89xf477-ND9RKpfFdbUPqmgRUldk6nWxjXYpPco4xzwuIUsL7k4TEdOZHt1J9jHJ2v_h_dv7tlL08YtdG-W4dg-_3zoinYH4AdRtibI39LR6Ccu_6X_-Ue9fLwfUp7c2x8H-SBpuTn34X-mE</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1289145584</pqid></control><display><type>article</type><title>Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Giusti, Betti ; Gori, Anna Maria ; Marcucci, Rossella ; Sestini, Ilaria ; Saracini, Claudia ; Sticchi, Elena ; Gensini, Francesca ; Fatini, Cinzia ; Abbate, Rosanna ; Gensini, Gian Franco</creator><contributor>Gwinn, Katrina</contributor><creatorcontrib>Giusti, Betti ; Gori, Anna Maria ; Marcucci, Rossella ; Sestini, Ilaria ; Saracini, Claudia ; Sticchi, Elena ; Gensini, Francesca ; Fatini, Cinzia ; Abbate, Rosanna ; Gensini, Gian Franco ; Gwinn, Katrina</creatorcontrib><description>Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF. 456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method. The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 micromol/L; p&lt;0.0001). In both populations, a genotype-phenotype association (p&lt;0.0001) between Hcy and C677T MTHFR polymorphism was observed; in controls a significant (p = 0.029) association between tHcy and -786C/T eNOS polymorphism was also observed. At the multivariate analysis the NVAF risk significantly increased in the upper quartiles of Hcy compared to the lowest: OR from 2.8 (1.68-4.54 95%CI) in Q2 to 12.9 (7.96-21.06 95%CI) in Q4. Our data demonstrated the four polymorphisms, although able, at least in part, to affect Hcy, were not associated with an increased risk of NVAF per se or in combination.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0000495</identifier><identifier>PMID: 17551576</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - blood ; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Atrial fibrillation ; Atrial Fibrillation - blood ; Atrial Fibrillation - genetics ; Atrial Fibrillation - pathology ; Blood &amp; organ donations ; Cardiac arrhythmia ; Cardiovascular Disorders/Arrhythmias, Electrophysiology, and Pacing ; Case-Control Studies ; Clinical trials ; Colorectal cancer ; Critical care ; Deoxyribonucleic acid ; Diabetes ; Dihydrofolate reductase ; Disease susceptibility ; DNA ; Education ; Enzymes ; Epigenetics ; Female ; Fibrillation ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genetics and Genomics/Complex Traits ; Genetics and Genomics/Genetics of Disease ; Genetics and Genomics/Medical Genetics ; Genotype ; Genotype &amp; phenotype ; Haplotypes ; Homocysteine ; Humans ; Hyperhomocysteinemia ; Hyperhomocysteinemia - blood ; Hyperhomocysteinemia - complications ; Hyperhomocysteinemia - genetics ; Immunoassay ; Leukemia ; Male ; Marfan syndrome ; Metabolism ; Methylenetetrahydrofolate reductase ; Methylenetetrahydrofolate Reductase (NADPH2) - blood ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Middle Aged ; Multivariate analysis ; Mutation ; Nitric Oxide Synthase Type III - blood ; Nitric Oxide Synthase Type III - genetics ; Pathogenesis ; Pathology/Molecular Pathology ; Patients ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Prognosis ; Quartiles ; Risk analysis ; Risk Factors ; Tumors ; Young Adult</subject><ispartof>PloS one, 2007-06, Vol.2 (6), p.e495-e495</ispartof><rights>COPYRIGHT 2007 Public Library of Science</rights><rights>2007 Giusti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Giusti et al. 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c662t-1f5bc9220a1fc5ed3cfcac3eb31c4485a69ed71b58bc9f92bc829f20e337d1f23</citedby><cites>FETCH-LOGICAL-c662t-1f5bc9220a1fc5ed3cfcac3eb31c4485a69ed71b58bc9f92bc829f20e337d1f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1289145584/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1289145584?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,36994,44571,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17551576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gwinn, Katrina</contributor><creatorcontrib>Giusti, Betti</creatorcontrib><creatorcontrib>Gori, Anna Maria</creatorcontrib><creatorcontrib>Marcucci, Rossella</creatorcontrib><creatorcontrib>Sestini, Ilaria</creatorcontrib><creatorcontrib>Saracini, Claudia</creatorcontrib><creatorcontrib>Sticchi, Elena</creatorcontrib><creatorcontrib>Gensini, Francesca</creatorcontrib><creatorcontrib>Fatini, Cinzia</creatorcontrib><creatorcontrib>Abbate, Rosanna</creatorcontrib><creatorcontrib>Gensini, Gian Franco</creatorcontrib><title>Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF. 456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method. The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 micromol/L; p&lt;0.0001). In both populations, a genotype-phenotype association (p&lt;0.0001) between Hcy and C677T MTHFR polymorphism was observed; in controls a significant (p = 0.029) association between tHcy and -786C/T eNOS polymorphism was also observed. At the multivariate analysis the NVAF risk significantly increased in the upper quartiles of Hcy compared to the lowest: OR from 2.8 (1.68-4.54 95%CI) in Q2 to 12.9 (7.96-21.06 95%CI) in Q4. Our data demonstrated the four polymorphisms, although able, at least in part, to affect Hcy, were not associated with an increased risk of NVAF per se or in combination.</description><subject>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - blood</subject><subject>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - blood</subject><subject>Atrial Fibrillation - genetics</subject><subject>Atrial Fibrillation - pathology</subject><subject>Blood &amp; organ donations</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular Disorders/Arrhythmias, Electrophysiology, and Pacing</subject><subject>Case-Control Studies</subject><subject>Clinical trials</subject><subject>Colorectal cancer</subject><subject>Critical care</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>Dihydrofolate reductase</subject><subject>Disease susceptibility</subject><subject>DNA</subject><subject>Education</subject><subject>Enzymes</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Fibrillation</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics and Genomics/Complex Traits</subject><subject>Genetics and Genomics/Genetics of Disease</subject><subject>Genetics and Genomics/Medical Genetics</subject><subject>Genotype</subject><subject>Genotype &amp; phenotype</subject><subject>Haplotypes</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Hyperhomocysteinemia</subject><subject>Hyperhomocysteinemia - blood</subject><subject>Hyperhomocysteinemia - complications</subject><subject>Hyperhomocysteinemia - genetics</subject><subject>Immunoassay</subject><subject>Leukemia</subject><subject>Male</subject><subject>Marfan syndrome</subject><subject>Metabolism</subject><subject>Methylenetetrahydrofolate reductase</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - blood</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Mutation</subject><subject>Nitric Oxide Synthase Type III - blood</subject><subject>Nitric Oxide Synthase Type III - genetics</subject><subject>Pathogenesis</subject><subject>Pathology/Molecular Pathology</subject><subject>Patients</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Prognosis</subject><subject>Quartiles</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkluLEzEYhgdR3HX1H4gGhAXBdnOYHOZGKMXdLawWutXbkMkkbUo6mZ3MiP33pttRW_HC3CT58nyHvLxZ9hrBMSIcXW1C39bKj5tQmzFMKy_ok-wcFQSPGIbk6dH5LHsR4wZCSgRjz7MzxClFlLPzrF8Eb0CwYMo4XwJVV2CCcCGm4PPy9nrxAUwwp-wm3RaPjyMuGJheLYH5Mr8HK1Mb0AS_24a2Wbu4jcDVQHWtUx5YV7bOe9W5UIPYR22azpXOu273MntmlY_m1bBfZF-vPy2nt6O7-c1sOrkbacZwN0KWlrrAGCpkNTUV0VYrTUxJkM5zQRUrTMVRSUXCbIFLLXBhMTSE8ApZTC6yt4e6jQ9RDopFibAoUE6pyBMxOxBVUBvZtG6r2p0MysnHQGhXUrWd095IbpGxuFKCGZFjVhWF5lCUimBDcqhtqvVx6NaXW1NpU3et8idFT19qt5ar8F0iwZlA-2EuhwJteOhN7OTWJdmShrUJfZQcUi6ogAl89xf477-ND9RKpfFdbUPqmgRUldk6nWxjXYpPco4xzwuIUsL7k4TEdOZHt1J9jHJ2v_h_dv7tlL08YtdG-W4dg-_3zoinYH4AdRtibI39LR6Ccu_6X_-Ue9fLwfUp7c2x8H-SBpuTn34X-mE</recordid><startdate>20070606</startdate><enddate>20070606</enddate><creator>Giusti, Betti</creator><creator>Gori, Anna Maria</creator><creator>Marcucci, Rossella</creator><creator>Sestini, Ilaria</creator><creator>Saracini, Claudia</creator><creator>Sticchi, Elena</creator><creator>Gensini, Francesca</creator><creator>Fatini, Cinzia</creator><creator>Abbate, Rosanna</creator><creator>Gensini, Gian Franco</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20070606</creationdate><title>Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility</title><author>Giusti, Betti ; Gori, Anna Maria ; Marcucci, Rossella ; Sestini, Ilaria ; Saracini, Claudia ; Sticchi, Elena ; Gensini, Francesca ; Fatini, Cinzia ; Abbate, Rosanna ; Gensini, Gian Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c662t-1f5bc9220a1fc5ed3cfcac3eb31c4485a69ed71b58bc9f92bc829f20e337d1f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - blood</topic><topic>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - blood</topic><topic>Atrial Fibrillation - genetics</topic><topic>Atrial Fibrillation - pathology</topic><topic>Blood &amp; organ donations</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular Disorders/Arrhythmias, Electrophysiology, and Pacing</topic><topic>Case-Control Studies</topic><topic>Clinical trials</topic><topic>Colorectal cancer</topic><topic>Critical care</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes</topic><topic>Dihydrofolate reductase</topic><topic>Disease susceptibility</topic><topic>DNA</topic><topic>Education</topic><topic>Enzymes</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Fibrillation</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics and Genomics/Complex Traits</topic><topic>Genetics and Genomics/Genetics of Disease</topic><topic>Genetics and Genomics/Medical Genetics</topic><topic>Genotype</topic><topic>Genotype &amp; phenotype</topic><topic>Haplotypes</topic><topic>Homocysteine</topic><topic>Humans</topic><topic>Hyperhomocysteinemia</topic><topic>Hyperhomocysteinemia - blood</topic><topic>Hyperhomocysteinemia - complications</topic><topic>Hyperhomocysteinemia - genetics</topic><topic>Immunoassay</topic><topic>Leukemia</topic><topic>Male</topic><topic>Marfan syndrome</topic><topic>Metabolism</topic><topic>Methylenetetrahydrofolate reductase</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - blood</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Mutation</topic><topic>Nitric Oxide Synthase Type III - blood</topic><topic>Nitric Oxide Synthase Type III - genetics</topic><topic>Pathogenesis</topic><topic>Pathology/Molecular Pathology</topic><topic>Patients</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Prognosis</topic><topic>Quartiles</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giusti, Betti</creatorcontrib><creatorcontrib>Gori, Anna Maria</creatorcontrib><creatorcontrib>Marcucci, Rossella</creatorcontrib><creatorcontrib>Sestini, Ilaria</creatorcontrib><creatorcontrib>Saracini, Claudia</creatorcontrib><creatorcontrib>Sticchi, Elena</creatorcontrib><creatorcontrib>Gensini, Francesca</creatorcontrib><creatorcontrib>Fatini, Cinzia</creatorcontrib><creatorcontrib>Abbate, Rosanna</creatorcontrib><creatorcontrib>Gensini, Gian Franco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giusti, Betti</au><au>Gori, Anna Maria</au><au>Marcucci, Rossella</au><au>Sestini, Ilaria</au><au>Saracini, Claudia</au><au>Sticchi, Elena</au><au>Gensini, Francesca</au><au>Fatini, Cinzia</au><au>Abbate, Rosanna</au><au>Gensini, Gian Franco</au><au>Gwinn, Katrina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2007-06-06</date><risdate>2007</risdate><volume>2</volume><issue>6</issue><spage>e495</spage><epage>e495</epage><pages>e495-e495</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF. 456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method. The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 micromol/L; p&lt;0.0001). In both populations, a genotype-phenotype association (p&lt;0.0001) between Hcy and C677T MTHFR polymorphism was observed; in controls a significant (p = 0.029) association between tHcy and -786C/T eNOS polymorphism was also observed. At the multivariate analysis the NVAF risk significantly increased in the upper quartiles of Hcy compared to the lowest: OR from 2.8 (1.68-4.54 95%CI) in Q2 to 12.9 (7.96-21.06 95%CI) in Q4. Our data demonstrated the four polymorphisms, although able, at least in part, to affect Hcy, were not associated with an increased risk of NVAF per se or in combination.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>17551576</pmid><doi>10.1371/journal.pone.0000495</doi><tpages>e495</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2007-06, Vol.2 (6), p.e495-e495
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1289145584
source Publicly Available Content Database; PubMed Central
subjects 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - blood
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics
Adult
Aged
Aged, 80 and over
Analysis
Atrial fibrillation
Atrial Fibrillation - blood
Atrial Fibrillation - genetics
Atrial Fibrillation - pathology
Blood & organ donations
Cardiac arrhythmia
Cardiovascular Disorders/Arrhythmias, Electrophysiology, and Pacing
Case-Control Studies
Clinical trials
Colorectal cancer
Critical care
Deoxyribonucleic acid
Diabetes
Dihydrofolate reductase
Disease susceptibility
DNA
Education
Enzymes
Epigenetics
Female
Fibrillation
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genetics and Genomics/Complex Traits
Genetics and Genomics/Genetics of Disease
Genetics and Genomics/Medical Genetics
Genotype
Genotype & phenotype
Haplotypes
Homocysteine
Humans
Hyperhomocysteinemia
Hyperhomocysteinemia - blood
Hyperhomocysteinemia - complications
Hyperhomocysteinemia - genetics
Immunoassay
Leukemia
Male
Marfan syndrome
Metabolism
Methylenetetrahydrofolate reductase
Methylenetetrahydrofolate Reductase (NADPH2) - blood
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Multivariate analysis
Mutation
Nitric Oxide Synthase Type III - blood
Nitric Oxide Synthase Type III - genetics
Pathogenesis
Pathology/Molecular Pathology
Patients
Polymorphism
Polymorphism, Single Nucleotide - genetics
Prognosis
Quartiles
Risk analysis
Risk Factors
Tumors
Young Adult
title Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T16%3A56%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20C677T%20and%20A1298C%20MTHFR,%20A2756G%20MTR%20and%20-786%20C/T%20eNOS%20gene%20polymorphisms%20in%20atrial%20fibrillation%20susceptibility&rft.jtitle=PloS%20one&rft.au=Giusti,%20Betti&rft.date=2007-06-06&rft.volume=2&rft.issue=6&rft.spage=e495&rft.epage=e495&rft.pages=e495-e495&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0000495&rft_dat=%3Cgale_plos_%3EA472274901%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c662t-1f5bc9220a1fc5ed3cfcac3eb31c4485a69ed71b58bc9f92bc829f20e337d1f23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1289145584&rft_id=info:pmid/17551576&rft_galeid=A472274901&rfr_iscdi=true