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Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects

Brain-derived neurotrophic factor (BDNF) is an activity-dependent secreted protein that is critical to organization of neuronal networks and synaptic plasticity, especially in the hippocampus. We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline. CSF concentrat...

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Bibliographic Details
Published in:PloS one 2009-05, Vol.4 (5), p.e5424-e5424
Main Authors: Li, Ge, Peskind, Elaine R, Millard, Steven P, Chi, Peter, Sokal, Izabela, Yu, Chang-En, Bekris, Lynn M, Raskind, Murray A, Galasko, Douglas R, Montine, Thomas J
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Language:English
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Summary:Brain-derived neurotrophic factor (BDNF) is an activity-dependent secreted protein that is critical to organization of neuronal networks and synaptic plasticity, especially in the hippocampus. We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline. CSF concentration of BDNF, Abeta(42) and total tau were measured in 128 cognitively normal adults (Normals), 21 patients with Alzheimer's disease (AD), and nine patients with Mild Cognitive Impairment. Apolipoprotein E and BDNF SNP rs6265 genotype were determined. Neuropsychological tests were performed at baseline for all subjects and at follow-up visits in 50 Normals. CSF BDNF level was lower in AD patients compared to age-matched Normals (p = 0.02). CSF BDNF concentration decreased with age among Normals and was higher in women than men (both p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0005424