Anticipatory modulation of digit placement for grasp control is affected by Parkinson's disease

• Published in: PloS one 2010-02, Vol.5 (2), p.e9184-e9184
• Main Authors: Lukos, Jamie R, Lee, Dongpyo, Poizner, Howard, Santello, Marco
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Analysis of Variance; Basal ganglia; Biomechanical Phenomena; Circuits; Clinical trials; Cortex; Dextrous hands; Disease control; Dopamine; Drugs; Employee motivation; Female; Fingers - physiopathology; Ganglia; Hand Strength - physiology; Handedness; Humans; Huntingtons disease; Kinematics; Kinesiology; Kinetics; Lifts; Male; Medical research; Memory; Middle Aged; Modulation; Mortality; Motor Skills - physiology; Movement disorders; Neural networks; Neurodegenerative diseases; Neurological Disorders/Movement Disorders; Neuroscience/Behavioral Neuroscience; Neuroscience/Motor Systems; Parkinson Disease - physiopathology; Parkinson's disease; Parkinsons disease; Patients; Placement; Planning; Reaction kinetics; Sensorimotor system; Studies; Task Performance and Analysis
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0009184

Successful object manipulation relies on the ability to form and retrieve sensorimotor memories of digit forces and positions used in previous object lifts. Past studies of patients affected by Parkinson's disease (PD) have revealed that the basal ganglia play a crucial role in the acquisition and/or retrieval of sensorimotor memories for grasp control. Whereas it is known that PD impairs anticipatory control of digit forces during grasp, learning deficits associated with the planning of digit placement have yet to be explored. This question is motivated by recent work in healthy subjects revealing that anticipatory control of digit placement plays a crucial role for successful manipulation. We asked ten PD patients off medication and ten age-matched controls to reach, grasp and lift an object whose center of mass (CM) was on the left, right or center. The only task requirement was to minimize object roll during lift. The CM remained the same across consecutive trials (blocked condition) or was altered from trial to trial (random condition). We hypothesized that impairment of the basal ganglia-thalamo-cortical circuits in PD patients would reduce their ability to anticipate digit placement appropriate to the CM location. Consequently, we predicted that PD patients would exhibit similar digit placement in the blocked vs. random conditions and produce larger peak object rolls than that of control subjects. In the blocked condition, PD patients exhibited significantly weaker modulation of fingertip contact points to CM location and larger object roll than controls (p