Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations

Sarcoidosis is a poorly understood chronic inflammatory condition. Infiltration of affected organs by lymphocytes is characteristic of sarcoidosis, however previous reports suggest that circulating lymphocyte counts are low in some patients with the disease. The goal of this study was to evaluate ly...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2010-02, Vol.5 (2), p.e9088-e9088
Main Authors: Sweiss, Nadera J, Salloum, Rafah, Gandhi, Seema, Ghandi, Seema, Alegre, Maria-Luisa, Sawaqed, Ray, Badaracco, Maria, Pursell, Kenneth, Pitrak, David, Baughman, Robert P, Moller, David R, Garcia, Joe G N, Niewold, Timothy B
Format: Article
Language:English
Subjects:
Analysis
Anemia
Antigens, CD19 - blood
Blood
CD19 antigen
CD4 antigen
CD4-Positive T-Lymphocytes - pathology
CD8 antigen
CD8-Positive T-Lymphocytes - pathology
Correlation
Critical care
Cytometry
Flow Cytometry
Heart diseases
Humans
Immunology
Immunology/Immune Response
Infectious diseases
Infiltration
Inflammation
Laboratories
Lung diseases
Lymphocyte Count
Lymphocyte Subsets - pathology
Lymphocytes
Lymphocytopenia
Lymphopenia
Lymphopenia - blood
Lymphopenia - pathology
Medical research
Medical treatment
Medicine
Middle Aged
Organs
Patients
Peripheral blood
Respiratory tract diseases
Retrospective Studies
Rheumatology
Rheumatology/Autoimmunity, Autoimmune, and Inflammatory Diseases
Sarcoidosis
Sarcoidosis - blood
Sarcoidosis - pathology
Severity of Illness Index
Studies
Therapeutics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sarcoidosis is a poorly understood chronic inflammatory condition. Infiltration of affected organs by lymphocytes is characteristic of sarcoidosis, however previous reports suggest that circulating lymphocyte counts are low in some patients with the disease. The goal of this study was to evaluate lymphocyte subsets in peripheral blood in a cohort of sarcoidosis patients to determine the prevalence, severity, and clinical features associated with lymphopenia in major lymphocyte subsets. Lymphocyte subsets in 28 sarcoid patients were analyzed using flow cytometry to determine the percentage of CD4, CD8, and CD19 positive cells. Greater than 50% of patients had abnormally low CD4, CD8, or CD19 counts (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0009088