Differential expression of A-type and B-type lamins during hair cycling

Multiple genetic disorders caused by mutations that affect the proteins lamin A and C show strong skin phenotypes. These disorders include the premature aging disorders Hutchinson-Gilford progeria syndrome and mandibuloacral dysplasia, as well as restrictive dermopathy. Prior studies have shown that...

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Bibliographic Details
Published in:PloS one 2009-01, Vol.4 (1), p.e4114-e4114
Main Authors: Hanif, Mubashir, Rosengardten, Ylva, Sagelius, Hanna, Rozell, Björn, Eriksson, Maria
Format: Article
Language:English
Subjects:
Aging
Animals
Biological Phenomena
Cycles
Dermatology/Dermatologic Pathology
Dermatology/Pediatric Skin Diseases, including Genetic Diseases
Disorders
Drinking water
Dysplasia
Epidermis
Epidermis - metabolism
Follicles
Gene Expression
Genetic aspects
Genetic disorders
Genetics and Genomics/Animal Genetics
Genetics and Genomics/Disease Models
Genetics and Genomics/Gene Expression
Genetics and Genomics/Medical Genetics
Hair
Hair Follicle - metabolism
Hospitals
Hypodermis
Immunohistochemistry
Intermediate filament proteins
Lamins
Lamins - genetics
Lamins - metabolism
Mammals
Medicin och hälsovetenskap
Mice
Musculoskeletal system
Mutation
Nutrition
Polypeptides
Progeria
Progeria - genetics
Progeria - metabolism
Proteins
Proteins - genetics
Proteins - metabolism
Rodents
Skin
Stem cells
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Description
Summary:Multiple genetic disorders caused by mutations that affect the proteins lamin A and C show strong skin phenotypes. These disorders include the premature aging disorders Hutchinson-Gilford progeria syndrome and mandibuloacral dysplasia, as well as restrictive dermopathy. Prior studies have shown that the lamin A/C and B proteins are expressed in skin, but little is known about their normal expression in the different skin cell-types and during the hair cycle. Our immunohistochemical staining for lamins A/C and B in wild-type mice revealed strong expression in the basal cell layer of the epidermis, the outer root sheath, and the dermal papilla during all stages of the hair cycle. Lower expression of both lamins A/C and B was seen in suprabasal cells of the epidermis, in the hypodermis, and in the bulb of catagen follicles. In addition, we have utilized a previously described mouse model of Hutchinson-Gilford progeria syndrome and show here that the expression of progerin does not result in pronounced effects on hair cycling or the expression of lamin B.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0004114