Transmission in heteronymous spinal pathways is modified after stroke and related to motor incoordination

Changes in reflex spinal pathways after stroke have been shown to affect motor activity in agonist and antagonist muscles acting at the same joint. However, only a few studies have evaluated the heteronymous reflex pathways modulating motoneuronal activity at different joints. This study investigate...

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Bibliographic Details
Published in:PloS one 2009-01, Vol.4 (1), p.e4123-e4123
Main Authors: Dyer, Joseph-Omer, Maupas, Eric, de Andrade Melo, Sibele, Bourbonnais, Daniel, Fleury, Jean, Forget, Robert
Format: Article
Language:English
Subjects:
Adult
Aged
Ankle
Ataxia - etiology
Ataxia - physiopathology
Case-Control Studies
Coordination
Female
Femoral Nerve - physiopathology
Femur
Humans
Inhibition
Knee
Leg - innervation
Leg - physiopathology
Legs
Male
Middle Aged
Motor activity
Motor Neurons - physiology
Muscle Spasticity - etiology
Muscle Spasticity - physiopathology
Muscle, Skeletal - innervation
Muscle, Skeletal - physiopathology
Muscles
Neural Pathways - physiopathology
Neurological Disorders/Cerebrovascular Disease
Neuroscience/Motor Systems
Neuroscience/Neuronal Signaling Mechanisms
Paresis - etiology
Paresis - physiopathology
Pathways
Quadriceps muscle
Recovery
Recovery of Function - physiology
Reflex - physiology
Rodents
Spasticity
Stroke
Stroke - complications
Stroke - physiopathology
Tibial Nerve - physiopathology
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Summary:Changes in reflex spinal pathways after stroke have been shown to affect motor activity in agonist and antagonist muscles acting at the same joint. However, only a few studies have evaluated the heteronymous reflex pathways modulating motoneuronal activity at different joints. This study investigates whether there are changes in the spinal facilitatory and inhibitory pathways linking knee to ankle extensors and if such changes may be related to motor deficits after stroke. The early facilitation and later inhibition of soleus H reflex evoked by the stimulation of femoral nerve at 2 times the motor threshold of the quadriceps were assessed in 15 healthy participants and on the paretic and the non-paretic sides of 15 stroke participants. The relationships between this reflex modulation and the levels of motor recovery, coordination and spasticity were then studied. Results show a significant (Mann-Whitney U; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0004123