Low adiponectin levels are an independent predictor of mixed and non-calcified coronary atherosclerotic plaques

Atherosclerosis is the primary cause of coronary artery disease (CAD). There is increasing recognition that lesion composition rather than size determines the acute complications of atherosclerotic disease. Low serum adiponectin levels were reported to be associated with coronary artery disease and...

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Published in:PloS one 2009-03, Vol.4 (3), p.e4733-e4733
Main Authors: Broedl, Uli C, Lebherz, Corinna, Lehrke, Michael, Stark, Renee, Greif, Martin, Becker, Alexander, von Ziegler, Franz, Tittus, Janine, Reiser, Maximilian, Becker, Christoph, Göke, Burkhard, Parhofer, Klaus G, Leber, Alexander W
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - blood
Aged
Analysis
Angiography
Arteriosclerosis
Atherosclerosis
Bivariate analysis
Calcinosis
Cardiovascular disease
Cardiovascular Disorders/Cardiovascular Imaging
Cardiovascular Disorders/Coronary Artery Disease
Chest Pain
Complications
Coronary Angiography
Coronary artery
Coronary artery disease
Coronary Artery Disease - diagnosis
Coronary Artery Disease - etiology
Coronary Artery Disease - pathology
Coronary heart disease
Correlation analysis
Diabetes
Diabetes and Endocrinology
Female
Heart diseases
Humans
Kinases
Male
Middle Aged
Pain
Plaques
Predictive Value of Tests
Rodents
Stenosis
Tomography, X-Ray Computed
Tumor necrosis factor-TNF
Type 2 diabetes
Variability
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cited_by cdi_FETCH-LOGICAL-c662t-cb2f244a8d981a7f0a708dcd6f52f07872222b4db4024702c7d6eb1ac3bf24293
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creator Broedl, Uli C
Lebherz, Corinna
Lehrke, Michael
Stark, Renee
Greif, Martin
Becker, Alexander
von Ziegler, Franz
Tittus, Janine
Reiser, Maximilian
Becker, Christoph
Göke, Burkhard
Parhofer, Klaus G
Leber, Alexander W
description Atherosclerosis is the primary cause of coronary artery disease (CAD). There is increasing recognition that lesion composition rather than size determines the acute complications of atherosclerotic disease. Low serum adiponectin levels were reported to be associated with coronary artery disease and future incidence of acute coronary syndrome (ACS). The impact of adiponectin on lesion composition still remains to be determined. We measured serum adiponectin levels in 303 patients with stable typical or atypical chest pain, who underwent dual-source multi-slice CT-angiography to exclude coronary artery stenosis. Atherosclerotic plaques were classified as calcified, mixed or non-calcified. In bivariate analysis adiponectin levels were inversely correlated with total coronary plaque burden (r = -0.21, p = 0.0004), mixed (r = -0.20, p = 0.0007) and non-calcified plaques (r = -0.18, p = 0.003). No correlation was seen with calcified plaques (r = -0.05, p = 0.39). In a fully adjusted multivariate model adiponectin levels remained predictive of total plaque burden (estimate: -0.036, 95%CI: -0.052 to -0.020, p
doi_str_mv 10.1371/journal.pone.0004733
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There is increasing recognition that lesion composition rather than size determines the acute complications of atherosclerotic disease. Low serum adiponectin levels were reported to be associated with coronary artery disease and future incidence of acute coronary syndrome (ACS). The impact of adiponectin on lesion composition still remains to be determined. We measured serum adiponectin levels in 303 patients with stable typical or atypical chest pain, who underwent dual-source multi-slice CT-angiography to exclude coronary artery stenosis. Atherosclerotic plaques were classified as calcified, mixed or non-calcified. In bivariate analysis adiponectin levels were inversely correlated with total coronary plaque burden (r = -0.21, p = 0.0004), mixed (r = -0.20, p = 0.0007) and non-calcified plaques (r = -0.18, p = 0.003). No correlation was seen with calcified plaques (r = -0.05, p = 0.39). In a fully adjusted multivariate model adiponectin levels remained predictive of total plaque burden (estimate: -0.036, 95%CI: -0.052 to -0.020, p&lt;0.0001), mixed (estimate: -0.087, 95%CI: -0.132 to -0.042, p = 0.0001) and non-calcified plaques (estimate: -0.076, 95%CI: -0.115 to -0.038, p = 0.0001). Adiponectin levels were not associated with calcified plaques (estimate: -0.021, 95% CI: -0.043 to -0.001, p = 0.06). Since the majority of coronary plaques was calcified, adiponectin levels account for only 3% of the variability in total plaque number. In contrast, adiponectin accounts for approximately 20% of the variability in mixed and non-calcified plaque burden. Adiponectin levels predict mixed and non-calcified coronary atherosclerotic plaque burden. 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There is increasing recognition that lesion composition rather than size determines the acute complications of atherosclerotic disease. Low serum adiponectin levels were reported to be associated with coronary artery disease and future incidence of acute coronary syndrome (ACS). The impact of adiponectin on lesion composition still remains to be determined. We measured serum adiponectin levels in 303 patients with stable typical or atypical chest pain, who underwent dual-source multi-slice CT-angiography to exclude coronary artery stenosis. Atherosclerotic plaques were classified as calcified, mixed or non-calcified. In bivariate analysis adiponectin levels were inversely correlated with total coronary plaque burden (r = -0.21, p = 0.0004), mixed (r = -0.20, p = 0.0007) and non-calcified plaques (r = -0.18, p = 0.003). No correlation was seen with calcified plaques (r = -0.05, p = 0.39). In a fully adjusted multivariate model adiponectin levels remained predictive of total plaque burden (estimate: -0.036, 95%CI: -0.052 to -0.020, p&lt;0.0001), mixed (estimate: -0.087, 95%CI: -0.132 to -0.042, p = 0.0001) and non-calcified plaques (estimate: -0.076, 95%CI: -0.115 to -0.038, p = 0.0001). Adiponectin levels were not associated with calcified plaques (estimate: -0.021, 95% CI: -0.043 to -0.001, p = 0.06). Since the majority of coronary plaques was calcified, adiponectin levels account for only 3% of the variability in total plaque number. In contrast, adiponectin accounts for approximately 20% of the variability in mixed and non-calcified plaque burden. Adiponectin levels predict mixed and non-calcified coronary atherosclerotic plaque burden. Low adiponectin levels may contribute to coronary plaque vulnerability and may thus play a role in the pathophysiology of ACS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19266101</pmid><doi>10.1371/journal.pone.0004733</doi><tpages>e4733</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
ispartof PloS one, 2009-03, Vol.4 (3), p.e4733-e4733
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1932-6203
language eng
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source Publicly Available Content Database; PubMed Central
subjects Adiponectin
Adiponectin - blood
Aged
Analysis
Angiography
Arteriosclerosis
Atherosclerosis
Bivariate analysis
Calcinosis
Cardiovascular disease
Cardiovascular Disorders/Cardiovascular Imaging
Cardiovascular Disorders/Coronary Artery Disease
Chest Pain
Complications
Coronary Angiography
Coronary artery
Coronary artery disease
Coronary Artery Disease - diagnosis
Coronary Artery Disease - etiology
Coronary Artery Disease - pathology
Coronary heart disease
Correlation analysis
Diabetes
Diabetes and Endocrinology
Female
Heart diseases
Humans
Kinases
Male
Middle Aged
Pain
Plaques
Predictive Value of Tests
Rodents
Stenosis
Tomography, X-Ray Computed
Tumor necrosis factor-TNF
Type 2 diabetes
Variability
title Low adiponectin levels are an independent predictor of mixed and non-calcified coronary atherosclerotic plaques
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