Genetic variance in the adiponutrin gene family and childhood obesity

• Published in: PloS one 2009-04, Vol.4 (4), p.e5327-e5327
• Main Authors: Johansson, Lovisa E, Johansson, Lina M, Danielsson, Pernilla, Norgren, Svante, Johansson, Stina, Marcus, Claude, Ridderstråle, Martin
• Format: Article
• Language: English
• Subjects: Adipocytes; Adolescent; Adolescents; Age; Body composition; Case-Control Studies; Childhood; Children; Diabetes; Diabetes and Endocrinology/Obesity; Enzymes; Female; Gender; Genes; Genetic diversity; Genetic variance; Genetic Variation; Genetics and Genomics/Complex Traits; Genotype; Glucose; Health aspects; Health Sciences; Humans; Hälsovetenskap; Insulin; Insulin resistance; Insulin Resistance - genetics; Lipase - genetics; Lipase - metabolism; Lipids; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Membrane Proteins - genetics; Minority & ethnic groups; Nutrition and Dietetics; Näringslära; Obesity; Obesity - genetics; Obesity - metabolism; Obesity in children; Pathogenesis; Pediatrics; Pediatrics and Child Health; Phenotypes; Polymorphism, Single Nucleotide; Proteins; Proteins - genetics; Proteins - metabolism; Science; Sensitivity; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Teenagers; Type 2 diabetes
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0005327

The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adolescent obesity. Polymorphisms in the five genes of the adiponutrin gene family were selected and genotyped using the Sequenom platform in a childhood and adolescent obesity case-control study. Six variants in PNPLA1 showed association with obesity (rs9380559, rs12212459, rs1467912, rs4713951, rs10947600, and rs12199580, p0.05). When analyzing these SNPs in relation to phenotypes, two SNPs in the PNPLA3 gene showed association with insulin sensitivity (rs12483959: beta = -0.053, p = 0.016, and rs2072907: beta = -0.049, p = 0.024). No associations were seen for PNPLA2, PNPLA4, and PNPLA5. Genetic variation in the adiponutrin gene family does not seem to contribute strongly to obesity in children and adolescents. PNPLA1 exhibited a modest effect on obesity and PNPLA3 on insulin sensitivity. These data, however, require confirmation in other cohorts and ethnic groups.