Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patients

Most HIV-infected patients receiving virologically suppressive antiretroviral therapy continue to have abnormal, generalized T cell activation. We explored whether the degree of ongoing cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) replication was assoc...

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Bibliographic Details
Published in:PloS one 2009-04, Vol.4 (4), p.e5277-e5277
Main Authors: Jacobson, Mark A, Ditmer, Dirk P, Sinclair, Elizabeth, Martin, Jeffrey N, Deeks, Steven G, Hunt, Peter, Mocarski, Edward S, Shiboski, Caroline
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiviral agents
Base Sequence
Care and treatment
CD38 antigen
CD4 antigen
CD4 Lymphocyte Count
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Cell activation
Cytomegalovirus
Deoxyribonucleic acid
DNA
DNA Primers
Epstein-Barr virus
Female
Genomes
Herpes viruses
Highly active antiretroviral therapy
Histocompatibility antigen HLA
HIV
HIV (Viruses)
HIV infection
HIV Infections - drug therapy
HIV Infections - immunology
HIV patients
Human cytomegalovirus
Human herpesvirus
Human immunodeficiency virus
Humans
Immunology/Immunomodulation
Immunophenotyping
Infectious Diseases/HIV Infection and AIDS
Infectious Diseases/Viral Infections
Kaposi's sarcoma
Kaposi's sarcoma-associated herpesvirus
Kaposis sarcoma
Lymphocyte Activation
Lymphocytes T
Male
Middle Aged
Multiplexing
Patients
Peripheral blood mononuclear cells
Polymerase Chain Reaction
Replication
Ribonucleic acid
RNA
Saliva
Sarcoma
Simplexvirus - physiology
T cell receptors
T cells
Therapy
Virus Replication
Viruses
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Description
Summary:Most HIV-infected patients receiving virologically suppressive antiretroviral therapy continue to have abnormal, generalized T cell activation. We explored whether the degree of ongoing cytomegalovirus (CMV), Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) replication was associated with higher virus-specific T cell activation and the failure to achieve normal absolute CD4+ T cell counts in the face of long-term suppressive antiretroviral therapy. Longitudinally collected PBMC and saliva specimens obtained from HIV-infected patients on effective antiretroviral therapy for at least one year (plasma HIV RNA 10% and plateau absolute CD4+ T cell counts
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0005277