2009 Swine-Origin Influenza A (H1N1) Resembles Previous Influenza Isolates

Background: In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2009-07, Vol.4 (7), p.e6402-e6402
Main Authors: Kingsford, Carl, Nagarajan, Niranjan, Salzberg, Steven L
Format: Article
Language:English
Subjects:
Bioinformatics
Biology
Capsid Proteins - genetics
Computer applications
Computer science
Epidemics
epidemiological studies
Evolutionary Biology/Bioinformatics
Evolutionary Biology/Genomics
genes
Genes, Viral
Genomics
hemagglutinins
Hogs
Infectious Diseases/Viral Infections
Influenza
Influenza A
Influenza A virus
Influenza A Virus, H1N1 Subtype - classification
Influenza A Virus, H1N1 Subtype - genetics
Influenza viruses
International conferences
isolation
Livestock
nucleotide sequences
Outbreaks
Phylogenetics
Proteins
Reassortant Viruses - classification
Reassortant Viruses - genetics
sialidase
Species Specificity
strain differences
strains
Swine
Swine flu
Swine influenza
swine-origin influenza viruses
viral diseases of animals and humans
viral proteins
Virology/Virus Evolution and Symbiosis
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the globe via human-to-human contact. Methodology: We conducted a comprehensive computational search of all available sequences of the surface proteins of H1N1 swine influenza isolates and found that a similar strain to S-OIV appeared in Thailand in 2000. The earlier isolates caused infections in pigs but only one sequenced human case, A/Thailand/271/2005 (H1N1). Significance: Differences between the Thai cases and S-OIV may help shed light on the ability of the current outbreak strain to spread rapidly among humans.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0006402