A novel role for Wnt/Ca2+ signaling in actin cytoskeleton remodeling and cell motility in prostate cancer

Wnt signaling is a critical regulatory pathway in development and disease. Very little is known about the mechanisms of Wnt signaling in prostate cancer, a leading cause of death in men. A quantitative analysis of the expression of Wnt5A protein in human tissue arrays, containing 600 prostate tissue...

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Bibliographic Details
Published in:PloS one 2010-05, Vol.5 (5), p.e10456-e10456
Main Authors: Wang, Qin, Symes, Andrew J, Kane, Corrina A, Freeman, Alex, Nariculam, Joseph, Munson, Philippa, Thrasivoulou, Christopher, Masters, John R W, Ahmed, Aamir
Format: Article
Language:English
Subjects:
Actin
Actins - metabolism
Architecture
Biomarkers
Ca2+/calmodulin-dependent protein kinase II
Calcium
Calcium - metabolism
Calcium Signaling
Calcium signalling
Calcium-binding protein
Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism
Calmodulin
Cancer
CD44 antigen
Cell adhesion & migration
Cell Biology/Cell Signaling
Cell Biology/Cytoskeleton
Cell Biology/Gene Expression
Cell Line, Tumor
Cell Movement
Cores
Cytoskeleton
Cytoskeleton - metabolism
Electron microscopy
Fibroblasts
Filopodia
Gene expression
Gene Expression Regulation, Neoplastic
Humans
Inhibition
Kinases
Male
Medical research
Melanoma
Metastasis
Microscopy, Confocal
Motility
Prostate - enzymology
Prostate - pathology
Prostate cancer
Prostatic Neoplasms - genetics
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Prostatic Neoplasms - ultrastructure
Protein arrays
Protein expression
Protein folding
Proteins
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
Pseudopodia - metabolism
Pseudopodia - ultrastructure
Quantitative analysis
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
Signal Transduction
Surgery
Transcription
Urology/Prostate Cancer
Wnt protein
Wnt Proteins - genetics
Wnt Proteins - metabolism
Wnt-5a Protein
Wound Healing
β-Catenin
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Description
Summary:Wnt signaling is a critical regulatory pathway in development and disease. Very little is known about the mechanisms of Wnt signaling in prostate cancer, a leading cause of death in men. A quantitative analysis of the expression of Wnt5A protein in human tissue arrays, containing 600 prostate tissue cores, showed >50% increase in malignant compared to benign cores (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0010456