Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects

• Published in: PloS one 2010-07, Vol.5 (7), p.e11428-e11428
• Main Authors: Tam, Claudia Ha Ting, Ho, Janice Sin Ka, Wang, Ying, Lee, Heung Man, Lam, Vincent Kwok Lim, Germer, Soren, Martin, Mitchell, So, Wing Yee, Ma, Ronald Ching Wan, Chan, Juliana Chung Ngor, Ng, Maggie Chor Yin
• Format: Article
• Language: English
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adenosine; Adolescents; Adult; Adults; Alleles; Analysis; Asian Continental Ancestry Group - genetics; Beta cells; Binding sites; Blood Glucose - metabolism; Blood proteins; Catalysis; Chromosomes; Circadian rhythm; Diabetes; Diabetes and Endocrinology/Type 2 Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Fasting; Fasting - blood; Female; Gene expression; Gene loci; Genes; Genetic aspects; Genetics and Genomics/Complex Traits; Genetics and Genomics/Genetics of Disease; Genetics and Genomics/Medical Genetics; Genetics and Genomics/Population Genetics; Genomics; Genotype; Glucokinase; Glucokinase - genetics; Glucose; Glucose-6-Phosphatase - genetics; Homeostasis; Hospitals; Humans; Hyperglycemia; Insulin; Insulin secretion; Insulin-Secreting Cells - pathology; Insulin-Secreting Cells - physiology; Isoenzymes; Laboratory testing; Male; Medicine; Melatonin; Meta-analysis; Middle Aged; Pancreatic beta cells; Phosphatases; Plasma; Polymorphism, Single Nucleotide - genetics; Receptors, Melatonin - genetics; Rodents; Secretion; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Type 2 diabetes
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0011428

Previous studies identified melatonin receptor 1B (MTNR1B), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2), glucokinase (GCK) and glucokinase regulatory protein (GCKR) as candidate genes for type 2 diabetes (T2D) acting through elevated fasting plasma glucose (FPG). We examined the associations of the reported common variants of these genes with T2D and glucose homeostasis in three independent Chinese cohorts. Five single nucleotide polymorphisms (SNPs), MTNR1B rs10830963, G6PC2 rs16856187 and rs478333, GCK rs1799884 and GCKR rs780094, were genotyped in 1644 controls (583 adults and 1061 adolescents) and 1342 T2D patients. The G-allele of MTNR1B rs10830963 and the C-alleles of both G6PC2 rs16856187 and rs478333 were associated with higher FPG (0.0034