Neuromedin U and its putative Drosophila homolog hugin

Whether other cleavage products from vertebrates encode functional neuropeptides remains to be determined, but the high conservation between rat and human sequences in this region (36 of 38 identical amino acids) suggests an important function [7]. Administration of NmU causes suppression of feeding...

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Bibliographic Details
Published in:PLoS biology 2006-03, Vol.4 (3), p.e68-e68
Main Authors: Melcher, Christoph, Bader, Rüdiger, Walther, Steffen, Simakov, Oleg, Pankratz, Michael J
Format: Article
Language:English
Subjects:
Amino acids
Animal Behavior
Animals
Behavior
Biochemistry
Conserved sequence
Correspondence and Other Communications
Drosophila
Drosophila melanogaster - genetics
Drosophila melanogaster - metabolism
Drosophila Proteins - classification
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Evolution
Feeding
Genetics/Genomics/Gene Therapy
Homology
Humans
Hyperphagia
Medical research
Molecular Biology/Structural Biology
Neuromedin
Neurons - metabolism
Neuropeptides
Neuropeptides - classification
Neuropeptides - genetics
Neuropeptides - metabolism
Neuroscience
Nutrition
Peptides
Periplaneta americana
Physiology
Proteins
Vertebrates
Zoology
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Summary:Whether other cleavage products from vertebrates encode functional neuropeptides remains to be determined, but the high conservation between rat and human sequences in this region (36 of 38 identical amino acids) suggests an important function [7]. Administration of NmU causes suppression of feeding in rats [8], while NmU knockout in mice causes hyperphagia [9]; in Drosophila, overexpression of hugin causes suppression of growth and feeding [1,3], while blocking synaptic activity of hugin neurons causes increased feeding [1].
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.0040068