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Neuromedin U and its putative Drosophila homolog hugin
Whether other cleavage products from vertebrates encode functional neuropeptides remains to be determined, but the high conservation between rat and human sequences in this region (36 of 38 identical amino acids) suggests an important function [7]. Administration of NmU causes suppression of feeding...
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| Published in: | PLoS biology 2006-03, Vol.4 (3), p.e68-e68 |
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| creator | Melcher, Christoph Bader, Rüdiger Walther, Steffen Simakov, Oleg Pankratz, Michael J |
| description | Whether other cleavage products from vertebrates encode functional neuropeptides remains to be determined, but the high conservation between rat and human sequences in this region (36 of 38 identical amino acids) suggests an important function [7]. Administration of NmU causes suppression of feeding in rats [8], while NmU knockout in mice causes hyperphagia [9]; in Drosophila, overexpression of hugin causes suppression of growth and feeding [1,3], while blocking synaptic activity of hugin neurons causes increased feeding [1]. |
| doi_str_mv | 10.1371/journal.pbio.0040068 |
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This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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| subjects | Amino acids Animal Behavior Animals Behavior Biochemistry Conserved sequence Correspondence and Other Communications Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - classification Drosophila Proteins - genetics Drosophila Proteins - metabolism Evolution Feeding Genetics/Genomics/Gene Therapy Homology Humans Hyperphagia Medical research Molecular Biology/Structural Biology Neuromedin Neurons - metabolism Neuropeptides Neuropeptides - classification Neuropeptides - genetics Neuropeptides - metabolism Neuroscience Nutrition Peptides Periplaneta americana Physiology Proteins Vertebrates Zoology |
| title | Neuromedin U and its putative Drosophila homolog hugin |
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