A molecular link between albinism and visual deficits

Since OA1 mutations cause both retinal defects and pigment loss in RPE, and pigmented RPE produces far more of a molecule that is important for normal retinal development (called pigment epithelium-derived factor, or PEDF) than nonpigmented RPE does, the researchers wondered whether L-DOPA could inc...

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Bibliographic Details
Published in:PLoS biology 2008-09, Vol.6 (9), p.e248-e248
Main Author: Gross, Liza
Format: Article
Language:English
Subjects:
Biochemistry
Cell Biology
Cell culture
Defects
Developmental Biology
Dopamine
Ligands
Mutation
Ophthalmology
Proteins
Retina
Studies
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Summary:Since OA1 mutations cause both retinal defects and pigment loss in RPE, and pigmented RPE produces far more of a molecule that is important for normal retinal development (called pigment epithelium-derived factor, or PEDF) than nonpigmented RPE does, the researchers wondered whether L-DOPA could increase PEDF levels.-Sure enough, exposing RPE cells to L-DOPA led to a significant increase in-PEDF expression.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.0060248