Coordinate gene regulation during hematopoiesis is related to genomic organization

Gene loci are found in nuclear subcompartments that are related to their expression status. For instance, silent genes are often localized to heterochromatin and the nuclear periphery, whereas active genes tend to be found in the nuclear center. Evidence also suggests that chromosomes may be specifi...

Full description

Saved in:
Bibliographic Details
Published in:PLoS biology 2007-11, Vol.5 (11), p.e309-e309
Main Authors: Kosak, Steven T, Scalzo, David, Alworth, Sam V, Li, Fusheng, Palmer, Stephanie, Enver, Tariq, Lee, James S J, Groudine, Mark
Format: Article
Language:English
Subjects:
Animals
Associations
Cell Biology
Cell Differentiation
Cell Nucleus - genetics
Cells, Cultured
Chromosome Positioning - genetics
Chromosomes
Colonies & territories
Developmental Biology
Erythroid Cells - cytology
Gene expression
Gene Expression Regulation, Developmental
Gene loci
Genome
Genomes
Hematology
Hematopoiesis - genetics
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - physiology
Medical research
Mice
Molecular Biology
Neutrophils - cytology
Neutrophils - physiology
Oligonucleotide Array Sequence Analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gene loci are found in nuclear subcompartments that are related to their expression status. For instance, silent genes are often localized to heterochromatin and the nuclear periphery, whereas active genes tend to be found in the nuclear center. Evidence also suggests that chromosomes may be specifically positioned within the nucleus; however, the nature of this organization and how it is achieved are not yet fully understood. To examine whether gene regulation is related to a discernible pattern of genomic organization, we analyzed the linear arrangement of co-regulated genes along chromosomes and determined the organization of chromosomes during the differentiation of a hematopoietic progenitor to erythroid and neutrophil cell types. Our analysis reveals that there is a significant tendency for co-regulated genes to be proximal, which is related to the association of homologous chromosomes and the spatial juxtaposition of lineage-specific gene domains. We suggest that proximity in the form of chromosomal gene distribution and homolog association may be the basis for organizing the genome for coordinate gene regulation during cellular differentiation.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.0050309