The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS)

There is increasing recognition of the importance of B lymphocytes in the immunopathogenesis of multiple sclerosis (MS), encouraging the evaluation of B cell-associated biomarkers in the cerebrospinal fluid (CSF). We aimed to evaluate the relevance of the B cell chemoattractant CXCL13 as a prognosti...

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Bibliographic Details
Published in:PloS one 2010-08, Vol.5 (8), p.e11986-e11986
Main Authors: Brettschneider, Johannes, Czerwoniak, Anne, Senel, Makbule, Fang, Lubin, Kassubek, Jan, Pinkhardt, Elmar, Lauda, Florian, Kapfer, Tamara, Jesse, Sarah, Lehmensiek, Vera, Ludolph, Albert C, Otto, Markus, Tumani, Hayrettin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
B cells
B-Lymphocytes - cytology
B-Lymphocytes - virology
Biomarkers
Biomarkers - cerebrospinal fluid
Cell Count
Cerebrospinal fluid
Chemokine CXCL13 - cerebrospinal fluid
Chemokines
Conversion
Criteria
CXCL13 protein
Enzyme-linked immunosorbent assay
Female
Follow-Up Studies
Gadolinium
Growth factors
Humans
Immunoglobulins
Immunology
Immunology/Immune Response
Immunopathogenesis
Inflammation
Leukocytes
Lymphocytes
Lymphocytes B
Lymphoma
Lymphomas
Magnetic resonance
Magnetic Resonance Imaging
Male
Measles
Medical prognosis
Medical research
Middle Aged
Multiple sclerosis
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - diagnosis
Multiple Sclerosis - immunology
Nervous system
Neurological Disorders/Multiple Sclerosis and Related Disorders
Neurology
NMR
Nuclear magnetic resonance
Oligoclonal Bands - cerebrospinal fluid
Patients
Predictive Value of Tests
Prognosis
Recurrence
Rubella
Syndrome
Trends
Varicella
Varicella-zoster virus
Viruses
White blood cells
Young Adult
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Summary:There is increasing recognition of the importance of B lymphocytes in the immunopathogenesis of multiple sclerosis (MS), encouraging the evaluation of B cell-associated biomarkers in the cerebrospinal fluid (CSF). We aimed to evaluate the relevance of the B cell chemoattractant CXCL13 as a prognostic marker in patients with clinically isolated syndrome (CIS) regarding conversion to MS, and to compare it to Barkhof criteria in magnetic resonance imaging (MRI), oligoclonal bands (OCB) and the polyspecific intrathecal B cell response against measles, rubella and varicella zoster virus (MRZR). CXCL13 was determined in a prospective study over 2 years including 46 patients that remained CIS over follow-up (CIS-CIS), 45 patients that developed MS (CIS-RRMS), and 30 controls using ELISA. CSF CXCL13 was significantly elevated in CIS-RRMS as compared to CIS-CIS and controls (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0011986