The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS)

There is increasing recognition of the importance of B lymphocytes in the immunopathogenesis of multiple sclerosis (MS), encouraging the evaluation of B cell-associated biomarkers in the cerebrospinal fluid (CSF). We aimed to evaluate the relevance of the B cell chemoattractant CXCL13 as a prognosti...

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Published in:PloS one 2010-08, Vol.5 (8), p.e11986-e11986
Main Authors: Brettschneider, Johannes, Czerwoniak, Anne, Senel, Makbule, Fang, Lubin, Kassubek, Jan, Pinkhardt, Elmar, Lauda, Florian, Kapfer, Tamara, Jesse, Sarah, Lehmensiek, Vera, Ludolph, Albert C, Otto, Markus, Tumani, Hayrettin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
B cells
B-Lymphocytes - cytology
B-Lymphocytes - virology
Biomarkers
Biomarkers - cerebrospinal fluid
Cell Count
Cerebrospinal fluid
Chemokine CXCL13 - cerebrospinal fluid
Chemokines
Conversion
Criteria
CXCL13 protein
Enzyme-linked immunosorbent assay
Female
Follow-Up Studies
Gadolinium
Growth factors
Humans
Immunoglobulins
Immunology
Immunology/Immune Response
Immunopathogenesis
Inflammation
Leukocytes
Lymphocytes
Lymphocytes B
Lymphoma
Lymphomas
Magnetic resonance
Magnetic Resonance Imaging
Male
Measles
Medical prognosis
Medical research
Middle Aged
Multiple sclerosis
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - diagnosis
Multiple Sclerosis - immunology
Nervous system
Neurological Disorders/Multiple Sclerosis and Related Disorders
Neurology
NMR
Nuclear magnetic resonance
Oligoclonal Bands - cerebrospinal fluid
Patients
Predictive Value of Tests
Prognosis
Recurrence
Rubella
Syndrome
Trends
Varicella
Varicella-zoster virus
Viruses
White blood cells
Young Adult
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container_title PloS one
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creator Brettschneider, Johannes
Czerwoniak, Anne
Senel, Makbule
Fang, Lubin
Kassubek, Jan
Pinkhardt, Elmar
Lauda, Florian
Kapfer, Tamara
Jesse, Sarah
Lehmensiek, Vera
Ludolph, Albert C
Otto, Markus
Tumani, Hayrettin
description There is increasing recognition of the importance of B lymphocytes in the immunopathogenesis of multiple sclerosis (MS), encouraging the evaluation of B cell-associated biomarkers in the cerebrospinal fluid (CSF). We aimed to evaluate the relevance of the B cell chemoattractant CXCL13 as a prognostic marker in patients with clinically isolated syndrome (CIS) regarding conversion to MS, and to compare it to Barkhof criteria in magnetic resonance imaging (MRI), oligoclonal bands (OCB) and the polyspecific intrathecal B cell response against measles, rubella and varicella zoster virus (MRZR). CXCL13 was determined in a prospective study over 2 years including 46 patients that remained CIS over follow-up (CIS-CIS), 45 patients that developed MS (CIS-RRMS), and 30 controls using ELISA. CSF CXCL13 was significantly elevated in CIS-RRMS as compared to CIS-CIS and controls (p
doi_str_mv 10.1371/journal.pone.0011986
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We aimed to evaluate the relevance of the B cell chemoattractant CXCL13 as a prognostic marker in patients with clinically isolated syndrome (CIS) regarding conversion to MS, and to compare it to Barkhof criteria in magnetic resonance imaging (MRI), oligoclonal bands (OCB) and the polyspecific intrathecal B cell response against measles, rubella and varicella zoster virus (MRZR). CXCL13 was determined in a prospective study over 2 years including 46 patients that remained CIS over follow-up (CIS-CIS), 45 patients that developed MS (CIS-RRMS), and 30 controls using ELISA. CSF CXCL13 was significantly elevated in CIS-RRMS as compared to CIS-CIS and controls (p&lt;0.001). It was significantly elevated in CIS with OCB (p&lt;0.001), positive MRZR (p=0.04), and gadolinium enhancement in MRI (p=0.02) and showed a significant correlation with CSF leukocyte count (p&lt;0.001) and QIgG (p&lt;0.001). 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brettschneider, Johannes</au><au>Czerwoniak, Anne</au><au>Senel, Makbule</au><au>Fang, Lubin</au><au>Kassubek, Jan</au><au>Pinkhardt, Elmar</au><au>Lauda, Florian</au><au>Kapfer, Tamara</au><au>Jesse, Sarah</au><au>Lehmensiek, Vera</au><au>Ludolph, Albert C</au><au>Otto, Markus</au><au>Tumani, Hayrettin</au><au>Kleinschnitz, Christoph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS)</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2010-08-05</date><risdate>2010</risdate><volume>5</volume><issue>8</issue><spage>e11986</spage><epage>e11986</epage><pages>e11986-e11986</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>There is increasing recognition of the importance of B lymphocytes in the immunopathogenesis of multiple sclerosis (MS), encouraging the evaluation of B cell-associated biomarkers in the cerebrospinal fluid (CSF). We aimed to evaluate the relevance of the B cell chemoattractant CXCL13 as a prognostic marker in patients with clinically isolated syndrome (CIS) regarding conversion to MS, and to compare it to Barkhof criteria in magnetic resonance imaging (MRI), oligoclonal bands (OCB) and the polyspecific intrathecal B cell response against measles, rubella and varicella zoster virus (MRZR). CXCL13 was determined in a prospective study over 2 years including 46 patients that remained CIS over follow-up (CIS-CIS), 45 patients that developed MS (CIS-RRMS), and 30 controls using ELISA. CSF CXCL13 was significantly elevated in CIS-RRMS as compared to CIS-CIS and controls (p&lt;0.001). It was significantly elevated in CIS with OCB (p&lt;0.001), positive MRZR (p=0.04), and gadolinium enhancement in MRI (p=0.02) and showed a significant correlation with CSF leukocyte count (p&lt;0.001) and QIgG (p&lt;0.001). CXCL13 showed the best positive predictive value (PPV) of all parameters investigated (70%, 95%-CI: 53-84%), which could be further increased by combination with Barkhof criteria in MRI (80%). Our data indicate the relevance of CXCL13 in CIS to predict conversion to MS. It furthermore shows CXCL13 to be an important mediator in the inflammatory cascade associated with the polyspecific intrathecal B cell response that manifests itself in OCB and MRZR.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20700489</pmid><doi>10.1371/journal.pone.0011986</doi><tpages>e11986</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
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issn 1932-6203
1932-6203
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source Open Access: PubMed Central; Publicly Available Content Database
subjects Adolescent
Adult
Aged
B cells
B-Lymphocytes - cytology
B-Lymphocytes - virology
Biomarkers
Biomarkers - cerebrospinal fluid
Cell Count
Cerebrospinal fluid
Chemokine CXCL13 - cerebrospinal fluid
Chemokines
Conversion
Criteria
CXCL13 protein
Enzyme-linked immunosorbent assay
Female
Follow-Up Studies
Gadolinium
Growth factors
Humans
Immunoglobulins
Immunology
Immunology/Immune Response
Immunopathogenesis
Inflammation
Leukocytes
Lymphocytes
Lymphocytes B
Lymphoma
Lymphomas
Magnetic resonance
Magnetic Resonance Imaging
Male
Measles
Medical prognosis
Medical research
Middle Aged
Multiple sclerosis
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - diagnosis
Multiple Sclerosis - immunology
Nervous system
Neurological Disorders/Multiple Sclerosis and Related Disorders
Neurology
NMR
Nuclear magnetic resonance
Oligoclonal Bands - cerebrospinal fluid
Patients
Predictive Value of Tests
Prognosis
Recurrence
Rubella
Syndrome
Trends
Varicella
Varicella-zoster virus
Viruses
White blood cells
Young Adult
title The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS)
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