Loading…
A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d
Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. Chronic chorioamnionitis and villitis of unknown etiology represent maternal anti-fetal cellular rejection. Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there...
Saved in:
| Published in: | PloS one 2011-02, Vol.6 (2), p.e16806-e16806 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c6386-7df608ebe66b2f873998881a7634cd37aa92456d1ff09ee4968149bd1d4337723 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c6386-7df608ebe66b2f873998881a7634cd37aa92456d1ff09ee4968149bd1d4337723 |
| container_end_page | e16806 |
| container_issue | 2 |
| container_start_page | e16806 |
| container_title | PloS one |
| container_volume | 6 |
| creator | Lee, JoonHo Romero, Roberto Xu, Yi Kim, Jung-Sun Topping, Vanessa Yoo, Wonsuk Kusanovic, Juan Pedro Chaiworapongsa, Tinnakorn Hassan, Sonia S Yoon, Bo Hyun Kim, Chong Jai |
| description | Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. Chronic chorioamnionitis and villitis of unknown etiology represent maternal anti-fetal cellular rejection. Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth.
This cross-sectional study included women with (1) normal pregnancy and term delivery (n = 140) and (2) spontaneous preterm delivery (n = 140). We analyzed maternal and fetal sera for panel-reactive anti-HLA class I and class II antibodies, and determined C4d deposition on umbilical vein endothelium by immunohistochemistry. Maternal anti-HLA class I seropositivity in spontaneous preterm births was higher than in normal term births (48.6% vs. 32.1%, p = 0.005). Chronic chorioamnionitis was associated with a higher maternal anti-HLA class I seropositivity (p |
| doi_str_mv | 10.1371/journal.pone.0016806 |
| format | article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1292192647</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A476906224</galeid><doaj_id>oai_doaj_org_article_399f971ff9574fed86a2fe3f96e87d32</doaj_id><sourcerecordid>A476906224</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6386-7df608ebe66b2f873998881a7634cd37aa92456d1ff09ee4968149bd1d4337723</originalsourceid><addsrcrecordid>eNqNk2uLEzEUhgdR3HX1H4gOCIpgay7TXPwglOKlsLDg7WtIJydt6kxSk4y4P8T_a3rZZSsLynw44cxz3jc5yamqxxiNMeX49ToM0etuvAkexghhJhC7U51iScmIEUTv3lifVA9SWiM0oYKx-9UJwZQwwSan1e9pndzS6zxEqIOte51hK1trn93IQi7LCGtoswu-dr5OxS9rD2FI9SZCoft64WJevanbVQzetSWG6ILufSlx2aVXe7HV0GtfdzB8D-1lhl1yCX4XF8E42IGmnjXmYXXP6i7Bo0M8q76-f_dl9nF0fvFhPpuej1pWTjLixjIkYAGMLYgVnEophMCaM9q0hnKtJWkmzGBrkQRoJBO4kQuDTUMp54SeVU_3upsuJHXoaFKYSIIlYQ0vxHxPmKDXahNdr-OlCtqpXSLEpdIxu7YDVdyt5MVLTnhjwQimiQVqJQPBDd26vT24DYseTAs-R90diR7_8W6lluGnoohSiWQReHEQiOHHACmr3qUWum5_H0oijifFnP6TFBMiERWkKeSzv8jb23Cglrqc1HkbygbbraaaNpxJxMhOa3wLVT4DvWvLO7Wu5I8KXh4VFCbDr7zUQ0pq_vnT_7MX347Z5zfYFegur1Lohu0jTsdgswfbGFKKYK9vAyO1HbOrbqjtmKnDmJWyJzdv8rroaq7oHxw6I7o</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1292192647</pqid></control><display><type>article</type><title>A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Lee, JoonHo ; Romero, Roberto ; Xu, Yi ; Kim, Jung-Sun ; Topping, Vanessa ; Yoo, Wonsuk ; Kusanovic, Juan Pedro ; Chaiworapongsa, Tinnakorn ; Hassan, Sonia S ; Yoon, Bo Hyun ; Kim, Chong Jai</creator><contributor>Wang, Haibin</contributor><creatorcontrib>Lee, JoonHo ; Romero, Roberto ; Xu, Yi ; Kim, Jung-Sun ; Topping, Vanessa ; Yoo, Wonsuk ; Kusanovic, Juan Pedro ; Chaiworapongsa, Tinnakorn ; Hassan, Sonia S ; Yoon, Bo Hyun ; Kim, Chong Jai ; Wang, Haibin</creatorcontrib><description>Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. Chronic chorioamnionitis and villitis of unknown etiology represent maternal anti-fetal cellular rejection. Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth.
This cross-sectional study included women with (1) normal pregnancy and term delivery (n = 140) and (2) spontaneous preterm delivery (n = 140). We analyzed maternal and fetal sera for panel-reactive anti-HLA class I and class II antibodies, and determined C4d deposition on umbilical vein endothelium by immunohistochemistry. Maternal anti-HLA class I seropositivity in spontaneous preterm births was higher than in normal term births (48.6% vs. 32.1%, p = 0.005). Chronic chorioamnionitis was associated with a higher maternal anti-HLA class I seropositivity (p<0.01), significant in preterm and term birth. Villitis of unknown etiology was associated with increased maternal and fetal anti-HLA class I and II seropositivity (p<0.05, for each). Fetal anti-HLA seropositivity was closely related to maternal anti-HLA seropositivity in both groups (p<0.01, for each). C4d deposition on umbilical vein endothelium was more frequent in preterm labor than term labor (77.1% vs. 11.4%, p<0.001). Logistic regression analysis revealed that chronic chorioamnionitis (OR = 6.10, 95% CI 1.29-28.83), maternal anti-HLA class I seropositivity (OR = 5.90, 95% CI 1.60-21.83), and C4d deposition on umbilical vein endothelium (OR = 36.19, 95% CI 11.42-114.66) were associated with preterm labor and delivery.
A major subset of spontaneous preterm births has a signature of maternal anti-fetal cellular and antibody-mediated rejections with links to fetal graft-versus-host disease and alloimmune reactions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0016806</identifier><identifier>PMID: 21326865</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analysis ; Antibodies ; Antibodies - blood ; Antigens ; Birth ; Cardiovascular disease ; Childbirth & labor ; Childrens health ; Chorioamnionitis ; Chorioamnionitis - blood ; Chorioamnionitis - etiology ; Chorioamnionitis - immunology ; Chronic Disease ; Complement C4b - analysis ; Coronary vessels ; Cross-Sectional Studies ; Deposition ; Endothelium ; Etiology ; Female ; Fetus - immunology ; Fetuses ; Graft rejection ; Graft Rejection - immunology ; Graft-versus-host reaction ; Gynecology ; Histocompatibility antigen HLA ; Histocompatibility, Maternal-Fetal - immunology ; Histocompatibility, Maternal-Fetal - physiology ; HLA antigens ; HLA Antigens - immunology ; Humans ; Immunoglobulins ; Immunohistochemistry ; Infant, Newborn ; Labor ; Leukocytes ; Lymphocytes ; Maternal-Fetal Exchange - immunology ; Medicine ; Obstetrics ; Peptide Fragments - analysis ; Peptide Fragments - blood ; Preeclampsia ; Pregnancy ; Premature birth ; Premature Birth - blood ; Premature Birth - diagnosis ; Premature Birth - etiology ; Premature Birth - immunology ; Premature infants ; Regression analysis ; Rejection ; Transplantation ; Transplants & implants ; Umbilical vein ; White blood cells ; Womens health</subject><ispartof>PloS one, 2011-02, Vol.6 (2), p.e16806-e16806</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011. This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6386-7df608ebe66b2f873998881a7634cd37aa92456d1ff09ee4968149bd1d4337723</citedby><cites>FETCH-LOGICAL-c6386-7df608ebe66b2f873998881a7634cd37aa92456d1ff09ee4968149bd1d4337723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1292192647/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1292192647?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21326865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wang, Haibin</contributor><creatorcontrib>Lee, JoonHo</creatorcontrib><creatorcontrib>Romero, Roberto</creatorcontrib><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Kim, Jung-Sun</creatorcontrib><creatorcontrib>Topping, Vanessa</creatorcontrib><creatorcontrib>Yoo, Wonsuk</creatorcontrib><creatorcontrib>Kusanovic, Juan Pedro</creatorcontrib><creatorcontrib>Chaiworapongsa, Tinnakorn</creatorcontrib><creatorcontrib>Hassan, Sonia S</creatorcontrib><creatorcontrib>Yoon, Bo Hyun</creatorcontrib><creatorcontrib>Kim, Chong Jai</creatorcontrib><title>A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. Chronic chorioamnionitis and villitis of unknown etiology represent maternal anti-fetal cellular rejection. Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth.
This cross-sectional study included women with (1) normal pregnancy and term delivery (n = 140) and (2) spontaneous preterm delivery (n = 140). We analyzed maternal and fetal sera for panel-reactive anti-HLA class I and class II antibodies, and determined C4d deposition on umbilical vein endothelium by immunohistochemistry. Maternal anti-HLA class I seropositivity in spontaneous preterm births was higher than in normal term births (48.6% vs. 32.1%, p = 0.005). Chronic chorioamnionitis was associated with a higher maternal anti-HLA class I seropositivity (p<0.01), significant in preterm and term birth. Villitis of unknown etiology was associated with increased maternal and fetal anti-HLA class I and II seropositivity (p<0.05, for each). Fetal anti-HLA seropositivity was closely related to maternal anti-HLA seropositivity in both groups (p<0.01, for each). C4d deposition on umbilical vein endothelium was more frequent in preterm labor than term labor (77.1% vs. 11.4%, p<0.001). Logistic regression analysis revealed that chronic chorioamnionitis (OR = 6.10, 95% CI 1.29-28.83), maternal anti-HLA class I seropositivity (OR = 5.90, 95% CI 1.60-21.83), and C4d deposition on umbilical vein endothelium (OR = 36.19, 95% CI 11.42-114.66) were associated with preterm labor and delivery.
A major subset of spontaneous preterm births has a signature of maternal anti-fetal cellular and antibody-mediated rejections with links to fetal graft-versus-host disease and alloimmune reactions.</description><subject>Adult</subject><subject>Analysis</subject><subject>Antibodies</subject><subject>Antibodies - blood</subject><subject>Antigens</subject><subject>Birth</subject><subject>Cardiovascular disease</subject><subject>Childbirth & labor</subject><subject>Childrens health</subject><subject>Chorioamnionitis</subject><subject>Chorioamnionitis - blood</subject><subject>Chorioamnionitis - etiology</subject><subject>Chorioamnionitis - immunology</subject><subject>Chronic Disease</subject><subject>Complement C4b - analysis</subject><subject>Coronary vessels</subject><subject>Cross-Sectional Studies</subject><subject>Deposition</subject><subject>Endothelium</subject><subject>Etiology</subject><subject>Female</subject><subject>Fetus - immunology</subject><subject>Fetuses</subject><subject>Graft rejection</subject><subject>Graft Rejection - immunology</subject><subject>Graft-versus-host reaction</subject><subject>Gynecology</subject><subject>Histocompatibility antigen HLA</subject><subject>Histocompatibility, Maternal-Fetal - immunology</subject><subject>Histocompatibility, Maternal-Fetal - physiology</subject><subject>HLA antigens</subject><subject>HLA Antigens - immunology</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunohistochemistry</subject><subject>Infant, Newborn</subject><subject>Labor</subject><subject>Leukocytes</subject><subject>Lymphocytes</subject><subject>Maternal-Fetal Exchange - immunology</subject><subject>Medicine</subject><subject>Obstetrics</subject><subject>Peptide Fragments - analysis</subject><subject>Peptide Fragments - blood</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Premature birth</subject><subject>Premature Birth - blood</subject><subject>Premature Birth - diagnosis</subject><subject>Premature Birth - etiology</subject><subject>Premature Birth - immunology</subject><subject>Premature infants</subject><subject>Regression analysis</subject><subject>Rejection</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Umbilical vein</subject><subject>White blood cells</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk2uLEzEUhgdR3HX1H4gOCIpgay7TXPwglOKlsLDg7WtIJydt6kxSk4y4P8T_a3rZZSsLynw44cxz3jc5yamqxxiNMeX49ToM0etuvAkexghhJhC7U51iScmIEUTv3lifVA9SWiM0oYKx-9UJwZQwwSan1e9pndzS6zxEqIOte51hK1trn93IQi7LCGtoswu-dr5OxS9rD2FI9SZCoft64WJevanbVQzetSWG6ILufSlx2aVXe7HV0GtfdzB8D-1lhl1yCX4XF8E42IGmnjXmYXXP6i7Bo0M8q76-f_dl9nF0fvFhPpuej1pWTjLixjIkYAGMLYgVnEophMCaM9q0hnKtJWkmzGBrkQRoJBO4kQuDTUMp54SeVU_3upsuJHXoaFKYSIIlYQ0vxHxPmKDXahNdr-OlCtqpXSLEpdIxu7YDVdyt5MVLTnhjwQimiQVqJQPBDd26vT24DYseTAs-R90diR7_8W6lluGnoohSiWQReHEQiOHHACmr3qUWum5_H0oijifFnP6TFBMiERWkKeSzv8jb23Cglrqc1HkbygbbraaaNpxJxMhOa3wLVT4DvWvLO7Wu5I8KXh4VFCbDr7zUQ0pq_vnT_7MX347Z5zfYFegur1Lohu0jTsdgswfbGFKKYK9vAyO1HbOrbqjtmKnDmJWyJzdv8rroaq7oHxw6I7o</recordid><startdate>20110204</startdate><enddate>20110204</enddate><creator>Lee, JoonHo</creator><creator>Romero, Roberto</creator><creator>Xu, Yi</creator><creator>Kim, Jung-Sun</creator><creator>Topping, Vanessa</creator><creator>Yoo, Wonsuk</creator><creator>Kusanovic, Juan Pedro</creator><creator>Chaiworapongsa, Tinnakorn</creator><creator>Hassan, Sonia S</creator><creator>Yoon, Bo Hyun</creator><creator>Kim, Chong Jai</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>7U7</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110204</creationdate><title>A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d</title><author>Lee, JoonHo ; Romero, Roberto ; Xu, Yi ; Kim, Jung-Sun ; Topping, Vanessa ; Yoo, Wonsuk ; Kusanovic, Juan Pedro ; Chaiworapongsa, Tinnakorn ; Hassan, Sonia S ; Yoon, Bo Hyun ; Kim, Chong Jai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6386-7df608ebe66b2f873998881a7634cd37aa92456d1ff09ee4968149bd1d4337723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Antibodies</topic><topic>Antibodies - blood</topic><topic>Antigens</topic><topic>Birth</topic><topic>Cardiovascular disease</topic><topic>Childbirth & labor</topic><topic>Childrens health</topic><topic>Chorioamnionitis</topic><topic>Chorioamnionitis - blood</topic><topic>Chorioamnionitis - etiology</topic><topic>Chorioamnionitis - immunology</topic><topic>Chronic Disease</topic><topic>Complement C4b - analysis</topic><topic>Coronary vessels</topic><topic>Cross-Sectional Studies</topic><topic>Deposition</topic><topic>Endothelium</topic><topic>Etiology</topic><topic>Female</topic><topic>Fetus - immunology</topic><topic>Fetuses</topic><topic>Graft rejection</topic><topic>Graft Rejection - immunology</topic><topic>Graft-versus-host reaction</topic><topic>Gynecology</topic><topic>Histocompatibility antigen HLA</topic><topic>Histocompatibility, Maternal-Fetal - immunology</topic><topic>Histocompatibility, Maternal-Fetal - physiology</topic><topic>HLA antigens</topic><topic>HLA Antigens - immunology</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunohistochemistry</topic><topic>Infant, Newborn</topic><topic>Labor</topic><topic>Leukocytes</topic><topic>Lymphocytes</topic><topic>Maternal-Fetal Exchange - immunology</topic><topic>Medicine</topic><topic>Obstetrics</topic><topic>Peptide Fragments - analysis</topic><topic>Peptide Fragments - blood</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Premature birth</topic><topic>Premature Birth - blood</topic><topic>Premature Birth - diagnosis</topic><topic>Premature Birth - etiology</topic><topic>Premature Birth - immunology</topic><topic>Premature infants</topic><topic>Regression analysis</topic><topic>Rejection</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Umbilical vein</topic><topic>White blood cells</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, JoonHo</creatorcontrib><creatorcontrib>Romero, Roberto</creatorcontrib><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Kim, Jung-Sun</creatorcontrib><creatorcontrib>Topping, Vanessa</creatorcontrib><creatorcontrib>Yoo, Wonsuk</creatorcontrib><creatorcontrib>Kusanovic, Juan Pedro</creatorcontrib><creatorcontrib>Chaiworapongsa, Tinnakorn</creatorcontrib><creatorcontrib>Hassan, Sonia S</creatorcontrib><creatorcontrib>Yoon, Bo Hyun</creatorcontrib><creatorcontrib>Kim, Chong Jai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, JoonHo</au><au>Romero, Roberto</au><au>Xu, Yi</au><au>Kim, Jung-Sun</au><au>Topping, Vanessa</au><au>Yoo, Wonsuk</au><au>Kusanovic, Juan Pedro</au><au>Chaiworapongsa, Tinnakorn</au><au>Hassan, Sonia S</au><au>Yoon, Bo Hyun</au><au>Kim, Chong Jai</au><au>Wang, Haibin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-02-04</date><risdate>2011</risdate><volume>6</volume><issue>2</issue><spage>e16806</spage><epage>e16806</epage><pages>e16806-e16806</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. Chronic chorioamnionitis and villitis of unknown etiology represent maternal anti-fetal cellular rejection. Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth.
This cross-sectional study included women with (1) normal pregnancy and term delivery (n = 140) and (2) spontaneous preterm delivery (n = 140). We analyzed maternal and fetal sera for panel-reactive anti-HLA class I and class II antibodies, and determined C4d deposition on umbilical vein endothelium by immunohistochemistry. Maternal anti-HLA class I seropositivity in spontaneous preterm births was higher than in normal term births (48.6% vs. 32.1%, p = 0.005). Chronic chorioamnionitis was associated with a higher maternal anti-HLA class I seropositivity (p<0.01), significant in preterm and term birth. Villitis of unknown etiology was associated with increased maternal and fetal anti-HLA class I and II seropositivity (p<0.05, for each). Fetal anti-HLA seropositivity was closely related to maternal anti-HLA seropositivity in both groups (p<0.01, for each). C4d deposition on umbilical vein endothelium was more frequent in preterm labor than term labor (77.1% vs. 11.4%, p<0.001). Logistic regression analysis revealed that chronic chorioamnionitis (OR = 6.10, 95% CI 1.29-28.83), maternal anti-HLA class I seropositivity (OR = 5.90, 95% CI 1.60-21.83), and C4d deposition on umbilical vein endothelium (OR = 36.19, 95% CI 11.42-114.66) were associated with preterm labor and delivery.
A major subset of spontaneous preterm births has a signature of maternal anti-fetal cellular and antibody-mediated rejections with links to fetal graft-versus-host disease and alloimmune reactions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21326865</pmid><doi>10.1371/journal.pone.0016806</doi><tpages>e16806</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2011-02, Vol.6 (2), p.e16806-e16806 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1292192647 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Adult Analysis Antibodies Antibodies - blood Antigens Birth Cardiovascular disease Childbirth & labor Childrens health Chorioamnionitis Chorioamnionitis - blood Chorioamnionitis - etiology Chorioamnionitis - immunology Chronic Disease Complement C4b - analysis Coronary vessels Cross-Sectional Studies Deposition Endothelium Etiology Female Fetus - immunology Fetuses Graft rejection Graft Rejection - immunology Graft-versus-host reaction Gynecology Histocompatibility antigen HLA Histocompatibility, Maternal-Fetal - immunology Histocompatibility, Maternal-Fetal - physiology HLA antigens HLA Antigens - immunology Humans Immunoglobulins Immunohistochemistry Infant, Newborn Labor Leukocytes Lymphocytes Maternal-Fetal Exchange - immunology Medicine Obstetrics Peptide Fragments - analysis Peptide Fragments - blood Preeclampsia Pregnancy Premature birth Premature Birth - blood Premature Birth - diagnosis Premature Birth - etiology Premature Birth - immunology Premature infants Regression analysis Rejection Transplantation Transplants & implants Umbilical vein White blood cells Womens health |
| title | A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T03%3A16%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20signature%20of%20maternal%20anti-fetal%20rejection%20in%20spontaneous%20preterm%20birth:%20chronic%20chorioamnionitis,%20anti-human%20leukocyte%20antigen%20antibodies,%20and%20C4d&rft.jtitle=PloS%20one&rft.au=Lee,%20JoonHo&rft.date=2011-02-04&rft.volume=6&rft.issue=2&rft.spage=e16806&rft.epage=e16806&rft.pages=e16806-e16806&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0016806&rft_dat=%3Cgale_plos_%3EA476906224%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c6386-7df608ebe66b2f873998881a7634cd37aa92456d1ff09ee4968149bd1d4337723%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1292192647&rft_id=info:pmid/21326865&rft_galeid=A476906224&rfr_iscdi=true |