Resting network plasticity following brain injury

The purpose of this study was to examine neural network properties at separate time-points during recovery from traumatic brain injury (TBI) using graph theory. Whole-brain analyses of the topological properties of the fMRI signal were conducted in 6 participants at 3 months and 6 months following s...

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Bibliographic Details
Published in:PloS one 2009-12, Vol.4 (12), p.e8220-e8220
Main Authors: Nakamura, Toru, Hillary, Frank G, Biswal, Bharat B
Format: Article
Language:English
Subjects:
Adult
Adults
Alzheimer's disease
Alzheimers disease
Artificial neural networks
Behavior
Brain
Brain injuries
Brain Injuries - physiopathology
Brain mapping
Connectivity
Data recovery
Dentistry
Female
Functional magnetic resonance imaging
Graph theory
Head injuries
Humans
Injury analysis
Magnetic Resonance Imaging
Medical imaging
Memory
Methods
Middle Aged
Nerve Net - physiopathology
Neural networks
Neurological Disorders
Neurological Disorders/Neuroimaging
Neurological Disorders/Neurorehabilitation and Trauma
Neuronal Plasticity - physiology
Neuroscience/Theoretical Neuroscience
NMR
Nuclear magnetic resonance
Properties (attributes)
Radiology and Medical Imaging/Magnetic Resonance Imaging
Rest - physiology
Studies
Time Factors
Traumatic brain injury
Young Adult
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Summary:The purpose of this study was to examine neural network properties at separate time-points during recovery from traumatic brain injury (TBI) using graph theory. Whole-brain analyses of the topological properties of the fMRI signal were conducted in 6 participants at 3 months and 6 months following severe TBI. Results revealed alterations of network properties including a change in the degree distribution, reduced overall strength in connectivity, and increased "small-worldness" from 3 months to 6 months post injury. The findings here indicate that, during recovery from injury, the strength but not the number of network connections diminishes, so that over the course of recovery, the network begins to approximate what is observed in healthy adults. These are the first data examining functional connectivity in a disrupted neural system during recovery.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0008220