CXCR2 signaling protects oligodendrocytes and restricts demyelination in a mouse model of viral-induced demyelination

The functional role of ELR-positive CXC chemokines during viral-induced demyelination was assessed. Inoculation of the neuroattenuated JHM strain of mouse hepatitis virus (JHMV) into the CNS of susceptible mice results in an acute encephalomyelitis that evolves into a chronic demyelinating disease,...

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Bibliographic Details
Published in:PloS one 2010-06, Vol.5 (6), p.e11340-e11340
Main Authors: Hosking, Martin P, Tirotta, Emanuele, Ransohoff, Richard M, Lane, Thomas E
Format: Article
Language:English
Subjects:
Analysis
Animals
Apoptosis
Bcl-2 protein
Biochemistry
Brain research
Caspase
Caspase-3
Central nervous system
Chemokine CXCL1 - metabolism
Chemokine CXCL2 - metabolism
Chemokines
Chronic illnesses
Chronic infection
CXC chemokines
CXCR2 protein
Cytotoxicity
Demyelination
Dendritic cells
Disease
Disease Models, Animal
Encephalomyelitis
Health aspects
Hepatitis
Infection
Infections
Infectious Diseases/Infectious Diseases of the Nervous System
Inflammation
Inoculation
Ligands
Lymphocytes
Mathematical models
Mice
Mice, Inbred C57BL
Molecular biology
Multiple sclerosis
Multiple Sclerosis - metabolism
Multiple Sclerosis - pathology
Multiple Sclerosis - virology
Murine hepatitis virus
Murine hepatitis virus - physiology
Nervous system
Neurological Disorders/Infectious Diseases of the Nervous System
Neurological Disorders/Multiple Sclerosis and Related Disorders
Neuromodulation
Neutralization
Neutrophils
Oligodendrocytes
Oligodendroglia - metabolism
Oligodendroglia - pathology
Polymerase Chain Reaction
Progenitor cells
Proteins
Receptors, Interleukin-8B - metabolism
Rodents
Signal Transduction
Signaling
Spinal cord
Substantia alba
Up-Regulation
Viral infections
Virology
Viruses
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Summary:The functional role of ELR-positive CXC chemokines during viral-induced demyelination was assessed. Inoculation of the neuroattenuated JHM strain of mouse hepatitis virus (JHMV) into the CNS of susceptible mice results in an acute encephalomyelitis that evolves into a chronic demyelinating disease, modeling white matter pathology observed in the human demyelinating disease Multiple Sclerosis. JHMV infection induced the rapid and sustained expression of transcripts specific for the ELR+ chemokine ligands CXCL1 and CXCL2, as well as their binding receptor CXCR2, which was enriched within the spinal cord during chronic infection. Inhibiting CXCR2 signaling with neutralizing antiserum significantly (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0011340