Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population

Myelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (...

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Bibliographic Details
Published in:PloS one 2010-10, Vol.5 (10), p.e13662-e13662
Main Authors: Wang, Ti, Zeng, Zhen, Li, Tao, Liu, Jie, Li, Junyan, Li, You, Zhao, Qian, Wei, Zhiyun, Wang, Yang, Li, Baojie, Feng, Guoyin, He, Lin, Shi, Yongyong
Format: Article
Language:English
Subjects:
Analysis
Binding proteins
Bipolar disorder
Case-Control Studies
China
Copy number
Deoxyribonucleic acid
Depression (Mood disorder)
Depressive Disorder, Major - genetics
DNA
DNA-binding protein
DNA-Binding Proteins - genetics
Education
Ethnic Groups
Gene Dosage
Genes
Genetic aspects
Genetic Predisposition to Disease
Genetics
Genetics and Genomics/Medical Genetics
Genetics and Genomics/Population Genetics
Genomes
Haplotypes
Humans
Informed consent
Kinases
Laboratories
Medical research
Mental depression
Mental disorders
Mental health
Mental Health/Mood Disorders
Mental Health/Schizophrenia and Other Psychoses
Mentally ill persons
Myelin
Nervous system
Neurobiology
Neuropathology
Neurosciences
Patients
Physiology
Polymorphism, Single Nucleotide
Population
Protein binding
Schizophrenia
Single-nucleotide polymorphism
Statistical analysis
Transcription factors
Transcription Factors - genetics
Zinc
Zinc finger proteins
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Summary:Myelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether MYT1L also plays a role in MDD. In this study, 8 SNPs were analyzed in 1139 MDD patients and 1140 controls of Chinese Han origin. Statistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204). A haplotype of rs1617213 and rs6759709 G-C was also significant (permutated p = 0.00007). Our results indicate that MYT1L may be a potential risk gene for MDD in the Chinese Han population.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0013662