Correlation of global and gene-specific DNA methylation in maternal-infant pairs

The inheritance of DNA methylation patterns is a popular theory to explain the influence of parental genetic and environmental factors on the phenotype of their offspring but few studies have examined this relationship in humans. Using 120 paired maternal-umbilical cord blood samples randomly select...

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Bibliographic Details
Published in:PloS one 2010-10, Vol.5 (10), p.e13730
Main Authors: Kile, Molly L, Baccarelli, Andrea, Tarantini, Letizia, Hoffman, Elaine, Wright, Robert O, Christiani, David C
Format: Article
Language:English
Subjects:
Alzheimer's disease
Analysis
Arsenic
Bangladesh
Base Sequence
Blood
Cord blood
Correlation
CpG islands
Daughters
Deoxyribonucleic acid
DNA
DNA Methylation
DNA Primers
Environmental factors
Environmental health
Epidemiology
Epigenetic inheritance
Epigenetics
Families & family life
Female
Fetuses
Gender
Genes
Genetic aspects
Genetic research
Genetics and Genomics/Epigenetics
Homocysteine
Humans
Infant
Linear Models
Long Interspersed Nucleotide Elements
Metabolism
Methylation
Occupational health
Offspring
Oral cancer
p53 Protein
Parenting
Pregnancy
Promoter Regions, Genetic
Prospective Studies
Public health
Public Health and Epidemiology/Environmental Health
Public Health and Epidemiology/Epidemiology
Regression analysis
Regression models
Tumor proteins
Umbilical cord
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Summary:The inheritance of DNA methylation patterns is a popular theory to explain the influence of parental genetic and environmental factors on the phenotype of their offspring but few studies have examined this relationship in humans. Using 120 paired maternal-umbilical cord blood samples randomly selected from a prospective birth cohort in Bangladesh, we quantified DNA methylation by pyrosequencing seven CpG positions in the promoter region of p16, four CpG positions in the promoter region of p53, LINE-1 and Alu. Positive correlations were observed between maternal and umbilical cord blood at p16, LINE-1, and Alu but not p53. Multiple linear regression models observed a significant association between maternal and umbilical cord blood at LINE-1 and Alu (LINE-1: β = 0.63, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0013730