Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan

High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population. The objective of the present study was to assess the relationship of blood Pb to...

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Bibliographic Details
Published in:PloS one 2010-07, Vol.5 (7), p.e11706-e11706
Main Authors: Yakub, Mohsin, Iqbal, Mohammad Perwaiz
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Blood
Blood levels
Cardiovascular diseases
Cardiovascular system
Cross-Sectional Studies
Cyanocobalamin
Female
Females
Folic acid
Folic Acid - blood
Health risk assessment
Homocysteine
Homocysteine - blood
Humans
Hyperhomocysteinemia
Hyperhomocysteinemia - blood
Hyperhomocysteinemia - epidemiology
Income
Lead
Lead - blood
Lead content
Lead poisoning
Male
Males
Middle Aged
Older people
Pakistan - epidemiology
Phosphates
Population studies
Public Health and Epidemiology
Public Health and Epidemiology/Environmental Health
Public Health and Epidemiology/Occupational and Industrial Medicine
Pyridoxal Phosphate - blood
Studies
Surveys
Urban populations
Vitamin B12
Vitamin B6
Young Adult
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Summary:High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population. The objective of the present study was to assess the relationship of blood Pb to the risk of hyperhomocysteinemia in a low income urban population of Karachi, Pakistan. In a cross sectional survey, 872 healthy adults (355 males, 517 females; age 18-60 years) were recruited from a low income urban population of Karachi. Fasting venous blood was obtained and assessed for blood Pb and plasma/serum homocysteine, folate, pyridoxal phosphate (PLP, a coenzymic form of vitamin B6) and vitamin B12. The study population had median (IQR) blood Pb of 10.82 microg/dL (8.29-13.60). Prevalence of high blood Pb (levels>10 microg/dL) was higher in males compared to females (62.5% males vs 56% females; p value=0.05). Mean+/-SD/median (IQR) value of plasma homocysteine was significantly higher in the highest quartile of blood Pb compared to the lowest quartile 16.13+/-11.2 micromol/L vs 13.28+/-9.7micromol/L/13.15 (10.33-17.81) micromol/L vs 11.09 (8.65 14.31) micromol/L (p value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0011706