Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis

Colorectal cancer (CRC) remains one of the major cancer types and cancer related death worldwide. Sensitive, non-invasive biomarkers that can facilitate disease detection, staging and prediction of therapeutic outcome are highly desirable to improve survival rate and help to determine optimized trea...

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Published in:PloS one 2011-03, Vol.6 (3), p.e17745-e17745
Main Authors: Cheng, Hanyin, Zhang, Lina, Cogdell, David E, Zheng, Hong, Schetter, Aaron J, Nykter, Matti, Harris, Curtis C, Chen, Kexin, Hamilton, Stanley R, Zhang, Wei
Format: Article
Language:English
Subjects:
Analysis
Bioindicators
Biology
Biomarkers
Biomarkers, Tumor - blood
Blood plasma
Cancer
Cancer diagnosis
Cancer metastasis
Cancer research
Carcinoembryonic antigen
Collaboration
Colon
Colon cancer
Colonic Neoplasms - blood
Colonic Neoplasms - diagnosis
Colonic Neoplasms - pathology
Colorectal cancer
Colorectal carcinoma
Development and progression
Disease
Disease detection
Epidemiology
Female
Health aspects
Hospitals
Humans
Laboratories
Leukemia
Liver cancer
Male
Medical prognosis
Medical research
Medicine
Metastases
Metastasis
MicroRNA
MicroRNAs
MicroRNAs - blood
miRNA
Neoplasm Metastasis
Oral cancer
Ovarian cancer
Pathology
Polymerase chain reaction
Predictions
Prognosis
Prostate cancer
Regulators
Reverse Transcriptase Polymerase Chain Reaction
Reverse transcription
Ribonucleic acid
RNA
Sensitivity analysis
Studies
Survival
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cited_by cdi_FETCH-LOGICAL-c757t-23a105a213d218acfe99638da6c6b1bec60dfbe14db01af18f04f8c9f69b84273
cites cdi_FETCH-LOGICAL-c757t-23a105a213d218acfe99638da6c6b1bec60dfbe14db01af18f04f8c9f69b84273
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container_issue 3
container_start_page e17745
container_title PloS one
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creator Cheng, Hanyin
Zhang, Lina
Cogdell, David E
Zheng, Hong
Schetter, Aaron J
Nykter, Matti
Harris, Curtis C
Chen, Kexin
Hamilton, Stanley R
Zhang, Wei
description Colorectal cancer (CRC) remains one of the major cancer types and cancer related death worldwide. Sensitive, non-invasive biomarkers that can facilitate disease detection, staging and prediction of therapeutic outcome are highly desirable to improve survival rate and help to determine optimized treatment for CRC. The small non-coding RNAs, microRNAs (miRNAs), have recently been identified as critical regulators for various diseases including cancer and may represent a novel class of cancer biomarkers. The purpose of this study was to identify and validate circulating microRNAs in human plasma for use as such biomarkers in colon cancer. By using quantitative reverse transcription-polymerase chain reaction, we found that circulating miR-141 was significantly associated with stage IV colon cancer in a cohort of 102 plasma samples. Receiver operating characteristic (ROC) analysis was used to evaluate the sensitivity and specificity of candidate plasma microRNA markers. We observed that combination of miR-141 and carcinoembryonic antigen (CEA), a widely used marker for CRC, further improved the accuracy of detection. These findings were validated in an independent cohort of 156 plasma samples collected at Tianjin, China. Furthermore, our analysis showed that high levels of plasma miR-141 predicted poor survival in both cohorts and that miR-141 was an independent prognostic factor for advanced colon cancer. We propose that plasma miR-141 may represent a novel biomarker that complements CEA in detecting colon cancer with distant metastasis and that high levels of miR-141 in plasma were associated with poor prognosis.
doi_str_mv 10.1371/journal.pone.0017745
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Sensitive, non-invasive biomarkers that can facilitate disease detection, staging and prediction of therapeutic outcome are highly desirable to improve survival rate and help to determine optimized treatment for CRC. The small non-coding RNAs, microRNAs (miRNAs), have recently been identified as critical regulators for various diseases including cancer and may represent a novel class of cancer biomarkers. The purpose of this study was to identify and validate circulating microRNAs in human plasma for use as such biomarkers in colon cancer. By using quantitative reverse transcription-polymerase chain reaction, we found that circulating miR-141 was significantly associated with stage IV colon cancer in a cohort of 102 plasma samples. Receiver operating characteristic (ROC) analysis was used to evaluate the sensitivity and specificity of candidate plasma microRNA markers. We observed that combination of miR-141 and carcinoembryonic antigen (CEA), a widely used marker for CRC, further improved the accuracy of detection. These findings were validated in an independent cohort of 156 plasma samples collected at Tianjin, China. Furthermore, our analysis showed that high levels of plasma miR-141 predicted poor survival in both cohorts and that miR-141 was an independent prognostic factor for advanced colon cancer. We propose that plasma miR-141 may represent a novel biomarker that complements CEA in detecting colon cancer with distant metastasis and that high levels of miR-141 in plasma were associated with poor prognosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0017745</identifier><identifier>PMID: 21445232</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Bioindicators ; Biology ; Biomarkers ; Biomarkers, Tumor - blood ; Blood plasma ; Cancer ; Cancer diagnosis ; Cancer metastasis ; Cancer research ; Carcinoembryonic antigen ; Collaboration ; Colon ; Colon cancer ; Colonic Neoplasms - blood ; Colonic Neoplasms - diagnosis ; Colonic Neoplasms - pathology ; Colorectal cancer ; Colorectal carcinoma ; Development and progression ; Disease ; Disease detection ; Epidemiology ; Female ; Health aspects ; Hospitals ; Humans ; Laboratories ; Leukemia ; Liver cancer ; Male ; Medical prognosis ; Medical research ; Medicine ; Metastases ; Metastasis ; MicroRNA ; MicroRNAs ; MicroRNAs - blood ; miRNA ; Neoplasm Metastasis ; Oral cancer ; Ovarian cancer ; Pathology ; Polymerase chain reaction ; Predictions ; Prognosis ; Prostate cancer ; Regulators ; Reverse Transcriptase Polymerase Chain Reaction ; Reverse transcription ; Ribonucleic acid ; RNA ; Sensitivity analysis ; Studies ; Survival</subject><ispartof>PloS one, 2011-03, Vol.6 (3), p.e17745-e17745</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>Copyright Public Library of Science Mar 2011</rights><rights>Cheng et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c757t-23a105a213d218acfe99638da6c6b1bec60dfbe14db01af18f04f8c9f69b84273</citedby><cites>FETCH-LOGICAL-c757t-23a105a213d218acfe99638da6c6b1bec60dfbe14db01af18f04f8c9f69b84273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1292380025/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1292380025?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,25736,27907,27908,36995,36996,44573,53774,53776,74877</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21445232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Navarro, Alfons</contributor><creatorcontrib>Cheng, Hanyin</creatorcontrib><creatorcontrib>Zhang, Lina</creatorcontrib><creatorcontrib>Cogdell, David E</creatorcontrib><creatorcontrib>Zheng, Hong</creatorcontrib><creatorcontrib>Schetter, Aaron J</creatorcontrib><creatorcontrib>Nykter, Matti</creatorcontrib><creatorcontrib>Harris, Curtis C</creatorcontrib><creatorcontrib>Chen, Kexin</creatorcontrib><creatorcontrib>Hamilton, Stanley R</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><title>Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Colorectal cancer (CRC) remains one of the major cancer types and cancer related death worldwide. 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We observed that combination of miR-141 and carcinoembryonic antigen (CEA), a widely used marker for CRC, further improved the accuracy of detection. These findings were validated in an independent cohort of 156 plasma samples collected at Tianjin, China. Furthermore, our analysis showed that high levels of plasma miR-141 predicted poor survival in both cohorts and that miR-141 was an independent prognostic factor for advanced colon cancer. We propose that plasma miR-141 may represent a novel biomarker that complements CEA in detecting colon cancer with distant metastasis and that high levels of miR-141 in plasma were associated with poor prognosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21445232</pmid><doi>10.1371/journal.pone.0017745</doi><tpages>e17745</tpages><oa>free_for_read</oa></addata></record>
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subjects Analysis
Bioindicators
Biology
Biomarkers
Biomarkers, Tumor - blood
Blood plasma
Cancer
Cancer diagnosis
Cancer metastasis
Cancer research
Carcinoembryonic antigen
Collaboration
Colon
Colon cancer
Colonic Neoplasms - blood
Colonic Neoplasms - diagnosis
Colonic Neoplasms - pathology
Colorectal cancer
Colorectal carcinoma
Development and progression
Disease
Disease detection
Epidemiology
Female
Health aspects
Hospitals
Humans
Laboratories
Leukemia
Liver cancer
Male
Medical prognosis
Medical research
Medicine
Metastases
Metastasis
MicroRNA
MicroRNAs
MicroRNAs - blood
miRNA
Neoplasm Metastasis
Oral cancer
Ovarian cancer
Pathology
Polymerase chain reaction
Predictions
Prognosis
Prostate cancer
Regulators
Reverse Transcriptase Polymerase Chain Reaction
Reverse transcription
Ribonucleic acid
RNA
Sensitivity analysis
Studies
Survival
title Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis
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