Body adiposity in later life and the incidence of dementia: the health in men study

To determine if adiposity in later life increases dementia hazard. Cohort study of 12,047 men aged 65-84 years living in Perth, Australia. Adiposity exposures were baseline body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR). We used the Western Australian Data Linkage Syste...

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Bibliographic Details
Published in:PloS one 2011-03, Vol.6 (3), p.e17902-e17902
Main Authors: Power, Brian D, Alfonso, Helman, Flicker, Leon, Hankey, Graeme J, Yeap, Bu B, Almeida, Osvaldo P
Format: Article
Language:English
Subjects:
Adipose tissue
Adiposity - physiology
Aged
Aged, 80 and over
Alcoholic beverages
Analysis
Australia - epidemiology
Biology
Biomarkers - metabolism
Body mass
Body Mass Index
Body size
Body weight
Cardiovascular diseases
Confidence intervals
Dementia
Dementia - epidemiology
Dementia - physiopathology
Dementia disorders
Demography
Diabetes mellitus
Dyslipidemia
Exercise
Follow-Up Studies
Health
Health hazards
Health risk assessment
Hip
Humans
Hypertension
Incidence
Life Style
Male
Medicine
Men
Mortality
Obesity
Older people
Overweight
Physical activity
Regression analysis
Regression models
Risk Factors
Smoking
Statistical analysis
Waist Circumference
Waist-Hip Ratio
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Summary:To determine if adiposity in later life increases dementia hazard. Cohort study of 12,047 men aged 65-84 years living in Perth, Australia. Adiposity exposures were baseline body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR). We used the Western Australian Data Linkage System (WADLS) to establish the presence of new cases of dementia between 1996 and 2009 according to the International Classification of Diseases (ICD). Crude and adjusted hazard ratio (HR, 95% confidence interval, 95%CI) of dementia for each adiposity marker was calculated using Cox regression models. Other measured factors included age, marital status, education, alcohol use, smoking, diet, physical activity, and prevalent hypertension, diabetes, dyslipidaemia and cardiovascular disease. Compared with men with BMI
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0017902