The effects of aging on the molecular and cellular composition of the prostate microenvironment

Advancing age is associated with substantial increases in the incidence rates of common diseases affecting the prostate gland including benign prostatic hyperplasia (BPH) and prostate carcinoma. The prostate is comprised of a functional secretory epithelium, a basal epithelium, and a supporting stro...

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Bibliographic Details
Published in:PloS one 2010-09, Vol.5 (9), p.e12501
Main Authors: Bianchi-Frias, Daniella, Vakar-Lopez, Funda, Coleman, Ilsa M, Plymate, Stephen R, Reed, May J, Nelson, Peter S
Format: Article
Language:English
Subjects:
Age
Aging
Aging - genetics
Aging - immunology
Aging - pathology
Analysis
Androgens
Animals
B cells
Bioinformatics
Biology
Biosynthesis
Cell Biology/Extra-Cellular Matrix
Cell Biology/Gene Expression
Cell growth
Collagen
Collagen (type I)
CYR61 protein
Developmental biology
Discordance
Electron microscopy
Epithelium
Extracellular matrix
Fibroblasts
Gene Expression
Genes
Genomes
Genotoxicity
Histology
Hyperplasia
Immunofluorescence
Inflammation
Lymphocytes
Lymphocytes B
Lymphocytes T
Macrophages
Male
Medical research
Mice
Mice, Inbred C57BL
Morphology
Oncology/Prostate Cancer
Organogenesis
Oxidative stress
Paracrine signalling
Pathology
Prostate
Prostate - immunology
Prostate - pathology
Prostate cancer
Prostate carcinoma
Proteins
Rodents
Senescence
Smooth muscle
Stroma
Stromal Cells - immunology
Structural members
Studies
T cells
Time Factors
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Summary:Advancing age is associated with substantial increases in the incidence rates of common diseases affecting the prostate gland including benign prostatic hyperplasia (BPH) and prostate carcinoma. The prostate is comprised of a functional secretory epithelium, a basal epithelium, and a supporting stroma comprised of structural elements, and a spectrum of cell types that includes smooth muscle cells, fibroblasts, and inflammatory cells. As reciprocal interactions between epithelium and stromal constituents are essential for normal organogenesis and serve to maintain normal functions, discordance within the stroma could permit or promote disease processes. In this study we sought to identify aging-associated alterations in the mouse prostate microenvironment that could influence pathology. We quantitated transcript levels in microdissected glandular-adjacent stroma from young (age 4 months) and old (age 20-24 months) C57BL/6 mice, and identified a significant change in the expression of 1259 genes (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0012501