Immunogenicity and cross-reactivity of 2009-2010 inactivated seasonal influenza vaccine in US adults and elderly

The campaign of 2009-2010 Northern Hemisphere seasonal vaccination was concurrent with the 2009 H1N1 pandemic. Using a hemagglutination inhibition (HAI) assay, we evaluated the immunogenicity and cross-reactivity of 2009-2010 inactivated trivalent influenza vaccine (TIV) in US adult and elderly popu...

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Bibliographic Details
Published in:PloS one 2011-01, Vol.6 (1), p.e16650-e16650
Main Authors: Xie, Hang, Jing, Xianghong, Li, Xing, Lin, Zhengshi, Plant, Ewan, Zoueva, Olga, Yang, Hong, Ye, Zhiping
Format: Article
Language:English
Subjects:
Adult
Adults
Aged
Antibodies
Antibodies, Viral
Antibody Formation
Antibody response
Avian flu
Cross Reactions - immunology
Cross-reactivity
Disease control
Elderly
Food
Geriatrics
Hemagglutination inhibition
Hemagglutination Tests
Humans
Illnesses
Immunity
Immunogenicity
Infections
Influenza
Influenza vaccines
Influenza Vaccines - immunology
Medical laboratories
Medicine
Military personnel
Northern Hemisphere
Older people
Pandemics
Seasons
Swine flu
United States
Vaccination
Vaccines
Viruses
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Summary:The campaign of 2009-2010 Northern Hemisphere seasonal vaccination was concurrent with the 2009 H1N1 pandemic. Using a hemagglutination inhibition (HAI) assay, we evaluated the immunogenicity and cross-reactivity of 2009-2010 inactivated trivalent influenza vaccine (TIV) in US adult and elderly populations. Vaccination of TIV resulted in a robust boost on the antibody response of all subjects to seasonal A/Brisbane/59/2007 (H1N1) and A/Uruguay/716/2007 (H3N2) with over 70% of recipients reaching a seroprotective titer of 40. B/Brisbane/60/2008 was the least immunogenic among the three seasonal vaccine strains with
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0016650