Large-scale candidate gene analysis of HDL particle features

HDL cholesterol (HDL-C) is an established marker of cardiovascular risk with significant genetic determination. However, HDL particles are not homogenous, and refined HDL phenotyping may improve insight into regulation of HDL metabolism. We therefore assessed HDL particles by NMR spectroscopy and co...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2011-01, Vol.6 (1), p.e14529-e14529
Main Authors: Kaess, Bernhard M, Tomaszewski, Maciej, Braund, Peter S, Stark, Klaus, Rafelt, Suzanne, Fischer, Marcus, Hardwick, Robert, Nelson, Christopher P, Debiec, Radoslaw, Huber, Fritz, Kremer, Werner, Kalbitzer, Hans Robert, Rose, Lynda M, Chasman, Daniel I, Hopewell, Jemma, Clarke, Robert, Burton, Paul R, Tobin, Martin D, Hengstenberg, Christian, Samani, Nilesh J
Format: Article
Language:English
Subjects:
Antilipemic agents
Association analysis
Cardiovascular Diseases
Cholesterol
Cholesterol, HDL - genetics
Cholesteryl ester transfer protein
Family
Female
Genes
Genetic aspects
Genetics and Genomics/Complex Traits
Genetics and Genomics/Genetics of Disease
Genetics and Genomics/Medical Genetics
Genetics and Genomics/Population Genetics
Genome-Wide Association Study - methods
Genomes
Genomics
Genotype
Genotypes
Health risks
High density lipoprotein
Humans
Lead
Lipase
Lipoproteins (high density)
Lipoproteins, HDL - genetics
Low density lipoprotein
Macular degeneration
Magnetic Resonance Spectroscopy
Male
Metabolism
NMR
NMR spectroscopy
Nuclear magnetic resonance
Nuclear magnetic resonance spectroscopy
Particle size
Particulates
Phenotype
Phenotyping
Phospholipid transfer protein
Physiological aspects
Single-nucleotide polymorphism
Spectroscopy
Spectrum analysis
United Kingdom
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:HDL cholesterol (HDL-C) is an established marker of cardiovascular risk with significant genetic determination. However, HDL particles are not homogenous, and refined HDL phenotyping may improve insight into regulation of HDL metabolism. We therefore assessed HDL particles by NMR spectroscopy and conducted a large-scale candidate gene association analysis. We measured plasma HDL-C and determined mean HDL particle size and particle number by NMR spectroscopy in 2024 individuals from 512 British Caucasian families. Genotypes were 49,094 SNPs in >2,100 cardiometabolic candidate genes/loci as represented on the HumanCVD BeadChip version 2. False discovery rates (FDR) were calculated to account for multiple testing. Analyses on classical HDL-C revealed significant associations (FDR
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0014529