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Short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice
Several brain disturbances have been described in association to type 1 diabetes in humans. In animal models, hippocampal pathological changes were reported together with cognitive deficits. The exposure to a variety of environmental stimuli during a certain period of time is able to prevent brain a...
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| Published in: | PloS one 2010-11, Vol.5 (11), p.e13993-e13993 |
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| creator | Beauquis, Juan Roig, Paulina De Nicola, Alejandro F Saravia, Flavia |
| description | Several brain disturbances have been described in association to type 1 diabetes in humans. In animal models, hippocampal pathological changes were reported together with cognitive deficits. The exposure to a variety of environmental stimuli during a certain period of time is able to prevent brain alterations and to improve learning and memory in conditions like stress, aging and neurodegenerative processes.
We explored the modulation of hippocampal alterations in streptozotocin-induced type 1 diabetic mice by environmental enrichment. In diabetic mice housed in standard conditions we found a reduction of adult neurogenesis in the dentate gyrus, decreased dendritic complexity in CA1 neurons and a smaller vascular fractional area in the dentate gyrus, compared with control animals in the same housing condition. A short exposure -10 days- to an enriched environment was able to enhance proliferation, survival and dendritic arborization of newborn neurons, to recover dendritic tree length and spine density of pyramidal CA1 neurons and to increase the vascular network of the dentate gyrus in diabetic animals.
The environmental complexity seems to constitute a strong stimulator competent to rescue the diabetic brain from neurodegenerative progression. |
| doi_str_mv | 10.1371/journal.pone.0013993 |
| format | article |
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We explored the modulation of hippocampal alterations in streptozotocin-induced type 1 diabetic mice by environmental enrichment. In diabetic mice housed in standard conditions we found a reduction of adult neurogenesis in the dentate gyrus, decreased dendritic complexity in CA1 neurons and a smaller vascular fractional area in the dentate gyrus, compared with control animals in the same housing condition. A short exposure -10 days- to an enriched environment was able to enhance proliferation, survival and dendritic arborization of newborn neurons, to recover dendritic tree length and spine density of pyramidal CA1 neurons and to increase the vascular network of the dentate gyrus in diabetic animals.
The environmental complexity seems to constitute a strong stimulator competent to rescue the diabetic brain from neurodegenerative progression.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0013993</identifier><identifier>PMID: 21085588</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aging ; Aging (artificial) ; Analysis ; Animal models ; Animals ; Animals, Newborn ; Behavior ; Biochemistry ; Biology ; Blood-brain barrier ; Brain ; Brain research ; CA1 Region, Hippocampal - physiopathology ; Cell Differentiation - physiology ; Cell Proliferation ; Cell survival ; Cell Survival - physiology ; Cognitive ability ; Complexity ; Councils ; Dendritic branching ; Dendritic spines ; Dendritic Spines - physiology ; Dentate gyrus ; Dentate Gyrus - blood supply ; Dentate Gyrus - physiopathology ; Diabetes ; Diabetes and Endocrinology/Type 1 Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - physiopathology ; Enrichment ; Environmental effects ; Exposure ; Fitness equipment ; Hippocampus ; Housing ; Housing, Animal - standards ; Inflammation ; Laboratory animals ; Learning ; Male ; Medicine ; Melatonin ; Memory ; Mice ; Mice, Inbred C57BL ; Neurogenesis ; Neurons ; Neurons - physiology ; Neuroscience ; Neuroscience/Neurobiology of Disease and Regeneration ; Oxidative stress ; Physiological aspects ; Pyramidal cells ; Pyramidal Cells - physiopathology ; Rodents ; Running ; Short term ; Spine ; Streptozocin ; Time Factors ; Type 1 diabetes ; Urine ; Vitamin E</subject><ispartof>PloS one, 2010-11, Vol.5 (11), p.e13993-e13993</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Beauquis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Beauquis et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c723t-a054cfc39c18fccf5c596a21287c1bdc6cc51c812be1a3e794059a1ef2ab8a863</citedby><cites>FETCH-LOGICAL-c723t-a054cfc39c18fccf5c596a21287c1bdc6cc51c812be1a3e794059a1ef2ab8a863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1295221761/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1295221761?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21085588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Giurfa, Martin</contributor><creatorcontrib>Beauquis, Juan</creatorcontrib><creatorcontrib>Roig, Paulina</creatorcontrib><creatorcontrib>De Nicola, Alejandro F</creatorcontrib><creatorcontrib>Saravia, Flavia</creatorcontrib><title>Short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Several brain disturbances have been described in association to type 1 diabetes in humans. In animal models, hippocampal pathological changes were reported together with cognitive deficits. The exposure to a variety of environmental stimuli during a certain period of time is able to prevent brain alterations and to improve learning and memory in conditions like stress, aging and neurodegenerative processes.
We explored the modulation of hippocampal alterations in streptozotocin-induced type 1 diabetic mice by environmental enrichment. In diabetic mice housed in standard conditions we found a reduction of adult neurogenesis in the dentate gyrus, decreased dendritic complexity in CA1 neurons and a smaller vascular fractional area in the dentate gyrus, compared with control animals in the same housing condition. A short exposure -10 days- to an enriched environment was able to enhance proliferation, survival and dendritic arborization of newborn neurons, to recover dendritic tree length and spine density of pyramidal CA1 neurons and to increase the vascular network of the dentate gyrus in diabetic animals.
The environmental complexity seems to constitute a strong stimulator competent to rescue the diabetic brain from neurodegenerative progression.</description><subject>Aging</subject><subject>Aging (artificial)</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Behavior</subject><subject>Biochemistry</subject><subject>Biology</subject><subject>Blood-brain barrier</subject><subject>Brain</subject><subject>Brain research</subject><subject>CA1 Region, Hippocampal - physiopathology</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Proliferation</subject><subject>Cell survival</subject><subject>Cell Survival - physiology</subject><subject>Cognitive ability</subject><subject>Complexity</subject><subject>Councils</subject><subject>Dendritic branching</subject><subject>Dendritic spines</subject><subject>Dendritic Spines - physiology</subject><subject>Dentate gyrus</subject><subject>Dentate Gyrus - 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Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beauquis, Juan</au><au>Roig, Paulina</au><au>De Nicola, Alejandro F</au><au>Saravia, Flavia</au><au>Giurfa, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2010-11-15</date><risdate>2010</risdate><volume>5</volume><issue>11</issue><spage>e13993</spage><epage>e13993</epage><pages>e13993-e13993</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Several brain disturbances have been described in association to type 1 diabetes in humans. In animal models, hippocampal pathological changes were reported together with cognitive deficits. The exposure to a variety of environmental stimuli during a certain period of time is able to prevent brain alterations and to improve learning and memory in conditions like stress, aging and neurodegenerative processes.
We explored the modulation of hippocampal alterations in streptozotocin-induced type 1 diabetic mice by environmental enrichment. In diabetic mice housed in standard conditions we found a reduction of adult neurogenesis in the dentate gyrus, decreased dendritic complexity in CA1 neurons and a smaller vascular fractional area in the dentate gyrus, compared with control animals in the same housing condition. A short exposure -10 days- to an enriched environment was able to enhance proliferation, survival and dendritic arborization of newborn neurons, to recover dendritic tree length and spine density of pyramidal CA1 neurons and to increase the vascular network of the dentate gyrus in diabetic animals.
The environmental complexity seems to constitute a strong stimulator competent to rescue the diabetic brain from neurodegenerative progression.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21085588</pmid><doi>10.1371/journal.pone.0013993</doi><tpages>e13993</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Aging (artificial) Analysis Animal models Animals Animals, Newborn Behavior Biochemistry Biology Blood-brain barrier Brain Brain research CA1 Region, Hippocampal - physiopathology Cell Differentiation - physiology Cell Proliferation Cell survival Cell Survival - physiology Cognitive ability Complexity Councils Dendritic branching Dendritic spines Dendritic Spines - physiology Dentate gyrus Dentate Gyrus - blood supply Dentate Gyrus - physiopathology Diabetes Diabetes and Endocrinology/Type 1 Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - physiopathology Enrichment Environmental effects Exposure Fitness equipment Hippocampus Housing Housing, Animal - standards Inflammation Laboratory animals Learning Male Medicine Melatonin Memory Mice Mice, Inbred C57BL Neurogenesis Neurons Neurons - physiology Neuroscience Neuroscience/Neurobiology of Disease and Regeneration Oxidative stress Physiological aspects Pyramidal cells Pyramidal Cells - physiopathology Rodents Running Short term Spine Streptozocin Time Factors Type 1 diabetes Urine Vitamin E |
| title | Short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice |
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