BOLD temporal dynamics of rat superior colliculus and lateral geniculate nucleus following short duration visual stimulation

The superior colliculus (SC) and lateral geniculate nucleus (LGN) are important subcortical structures for vision. Much of our understanding of vision was obtained using invasive and small field of view (FOV) techniques. In this study, we use non-invasive, large FOV blood oxygenation level-dependent...

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Bibliographic Details
Published in:PloS one 2011-04, Vol.6 (4), p.e18914-e18914
Main Authors: Lau, Condon, Zhou, Iris Y, Cheung, Matthew M, Chan, Kevin C, Wu, Ed X
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Automation
Biology
Blood
Blood vessels
Brain Mapping - methods
Colliculus
Cortex
Cortex (temporal)
Dilation
Echo surveys
Electrical stimuli
Engineering
Experiments
Eye
Ferric Compounds - chemistry
Field of view
Flashing
Functional magnetic resonance imaging
Geniculate Bodies - metabolism
Geniculate Bodies - pathology
Image acquisition
Iron
Iron oxides
Laboratories
Lateral geniculate nucleus
Magnetic Resonance Imaging - methods
Measurement techniques
Medical imaging
Medicine
Morphology
Nanoparticles
Nervous system
Neurons - metabolism
NMR
Nuclear magnetic resonance
Nuclei
Oxygen - metabolism
Oxygenation
Photic Stimulation - methods
Rats
Rats, Sprague-Dawley
Rodents
Signal processing
Stimulation
Studies
Superior Colliculi - metabolism
Superior Colliculi - pathology
Superior colliculus
Temporal lobe
Time Factors
Vision
Vision, Ocular
Visual cortex
Visual Pathways - physiology
Visual stimuli
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Summary:The superior colliculus (SC) and lateral geniculate nucleus (LGN) are important subcortical structures for vision. Much of our understanding of vision was obtained using invasive and small field of view (FOV) techniques. In this study, we use non-invasive, large FOV blood oxygenation level-dependent (BOLD) fMRI to measure the SC and LGN's response temporal dynamics following short duration (1 s) visual stimulation. Experiments are performed at 7 tesla on Sprague Dawley rats stimulated in one eye with flashing light. Gradient-echo and spin-echo sequences are used to provide complementary information. An anatomical image is acquired from one rat after injection of monocrystalline iron oxide nanoparticles (MION), a blood vessel contrast agent. BOLD responses are concentrated in the contralateral SC and LGN. The SC BOLD signal measured with gradient-echo rises to 50% of maximum amplitude (PEAK) 0.2±0.2 s before the LGN signal (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0018914