Functional connectivity fMRI of the rodent brain: comparison of functional connectivity networks in rat and mouse

At present, resting state functional MRI (rsfMRI) is increasingly used in human neuropathological research. The present study aims at implementing rsfMRI in mice, a species that holds the widest variety of neurological disease models. Moreover, by acquiring rsfMRI data with a comparable protocol for...

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Bibliographic Details
Published in:PloS one 2011-04, Vol.6 (4), p.e18876-e18876
Main Authors: Jonckers, Elisabeth, Van Audekerke, Johan, De Visscher, Geofrey, Van der Linden, Annemie, Verhoye, Marleen
Format: Article
Language:English
Subjects:
Albinism
Anesthesia
Animal models
Animals
Biology
Biomedical research
Brain
Brain mapping
Brain research
Cerebral Cortex - physiology
Comparative analysis
Cortex
Data acquisition
Functional magnetic resonance imaging
Independent component analysis
Laboratory animals
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medicine
Mice
Nervous system diseases
Neural networks
Parkinson's disease
Pathology
Physics
Rats
Reproducibility of Results
Rodents
Schizophrenia
Species Specificity
Studies
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Summary:At present, resting state functional MRI (rsfMRI) is increasingly used in human neuropathological research. The present study aims at implementing rsfMRI in mice, a species that holds the widest variety of neurological disease models. Moreover, by acquiring rsfMRI data with a comparable protocol for anesthesia, scanning and analysis, in both rats and mice we were able to compare findings obtained in both species. The outcome of rsfMRI is different for rats and mice and depends strongly on the applied number of components in the Independent Component Analysis (ICA). The most important difference was the appearance of unilateral cortical components for the mouse resting state data compared to bilateral rat cortical networks. Furthermore, a higher number of components was needed for the ICA analysis to separate different cortical regions in mice as compared to rats.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0018876