A user's guide to the encyclopedia of DNA elements (ENCODE)

The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a coll...

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Bibliographic Details
Published in:PLoS biology 2011-04, Vol.9 (4), p.e1001046-e1001046
Main Author: Consortium, The ENCODEProject
Format: Article
Language:English
Subjects:
Aspectes genètics
Base Sequence
Bioinformatics
Biology
Chromatin
Chromatin - metabolism
Colleges & universities
Conserved Sequence
Databases, Nucleic Acid
Deoxyribonucleic acid
DNA
DNA Methylation
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Gene Components
Gene Expression Regulation
Genetics
Genoma humà
Genome, Human
Genomics
Humans
Internet
Life Sciences
Medical research
Medicin och hälsovetenskap
Methylation
Models, Genetic
Physiological aspects
Proteïnes de la sang
Quality Control
RNA, Messenger - genetics
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
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Description
Summary:The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.1001046