Activated TLR signaling in atherosclerosis among women with lower Framingham risk score: the multi-ethnic study of atherosclerosis

Atherosclerosis is the leading cause of cardiovascular disease (CVD). Traditional risk factors can be used to identify individuals at high risk for developing CVD and are generally associated with the extent of atherosclerosis; however, substantial numbers of individuals at low or intermediate risk...

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Bibliographic Details
Published in:PloS one 2011-06, Vol.6 (6), p.e21067-e21067
Main Authors: Huang, Chiang-Ching, Liu, Kiang, Pope, Richard M, Du, Pan, Lin, Simon, Rajamannan, Nalini M, Huang, Qi-Quan, Jafari, Nadereh, Burke, Gregory L, Post, Wendy, Watson, Karol E, Johnson, Craig, Daviglus, Martha L, Lloyd-Jones, Donald M
Format: Article
Language:English
Subjects:
Acids
Aged
Algorithms
Arteriosclerosis
Atherosclerosis
Atherosclerosis - genetics
Atherosclerosis - metabolism
Bioinformatics
Biology
Blood
Calcification (ectopic)
Calcium
Cancer
Cardiology
Cardiovascular disease
Cardiovascular diseases
Case-Control Studies
Cell cycle
Cohort Studies
Collaboration
Coronary artery
Coronary vessels
Development and progression
Disease prevention
DNA microarrays
Ethnic Groups
Female
Gene expression
Gene Expression Profiling
Genes
Genomics
Health care
Health risks
Health sciences
Humans
Immune system
Inflammation
Inflammatory diseases
Innate immunity
Interleukin 1 receptors
Medicine
Middle Aged
Peripheral blood
Preventive medicine
Proteins
Receptors
Rheumatology
Risk analysis
Risk factors
Signal Transduction
Signaling
Studies
Toll-like receptors
Toll-Like Receptors - genetics
Toll-Like Receptors - metabolism
Ultrasonic imaging
Veins & arteries
Women's health
Womens health
Young adults
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Summary:Atherosclerosis is the leading cause of cardiovascular disease (CVD). Traditional risk factors can be used to identify individuals at high risk for developing CVD and are generally associated with the extent of atherosclerosis; however, substantial numbers of individuals at low or intermediate risk still develop atherosclerosis. A case-control study was performed using microarray gene expression profiling of peripheral blood from 119 healthy women in the Multi-Ethnic Study of Atherosclerosis cohort aged 50 or above. All participants had low (100 and carotid intima-media thickness (IMT) >1.0 mm, whereas controls (N = 71) had CAC
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0021067