Altered error processing following vascular thalamic damage: evidence from an antisaccade task

• Published in: PloS one 2011-06, Vol.6 (6), p.e21517-e21517
• Main Authors: Peterburs, Jutta, Pergola, Giulio, Koch, Benno, Schwarz, Michael, Hoffmann, Klaus-Peter, Daum, Irene, Bellebaum, Christian
• Format: Article
• Language: English
• Subjects: Adaptation; Adult; Age; Attenuation; Awareness - physiology; Behavior; Biology; Brain research; Case-Control Studies; Damage detection; Dopamine; Electroencephalography; Error analysis; Error correction & detection; Event-related potentials; Evoked Potentials - physiology; Eye; Eye movements; Feedback; Female; Humans; Information processing; Intelligence Tests; Latency; Magnetic Resonance Imaging; Male; Medical research; Medicine; Memory, Short-Term - physiology; Middle Aged; Mismatch negativity; Monitoring; Monitoring systems; Monkeys; Neurology; Neuropsychology; Neurosciences; Patients; Relaying; Saccades (Eye movements); Saccades - physiology; Saccadic eye movements; Stereotaxic Techniques; Task Performance and Analysis; Thalamus; Thalamus - blood supply; Thalamus - pathology; Thalamus - physiopathology; Time Factors; Transcranial magnetic stimulation
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0021517

Event-related potentials (ERP) research has identified a negative deflection within about 100 to 150 ms after an erroneous response--the error-related negativity (ERN)--as a correlate of awareness-independent error processing. The short latency suggests an internal error monitoring system acting rapidly based on central information such as an efference copy signal. Studies on monkeys and humans have identified the thalamus as an important relay station for efference copy signals of ongoing saccades. The present study investigated error processing on an antisaccade task with ERPs in six patients with focal vascular damage to the thalamus and 28 control subjects. ERN amplitudes were significantly reduced in the patients, with the strongest ERN attenuation being observed in two patients with right mediodorsal and ventrolateral and bilateral ventrolateral damage, respectively. Although the number of errors was significantly higher in the thalamic lesion patients, the degree of ERN attenuation did not correlate with the error rate in the patients. The present data underline the role of the thalamus for the online monitoring of saccadic eye movements, albeit not providing unequivocal evidence in favour of an exclusive role of a particular thalamic site being involved in performance monitoring. By relaying saccade-related efference copy signals, the thalamus appears to enable fast error processing. Furthermore early error processing based on internal information may contribute to error awareness which was reduced in the patients.