Pathway-based association analyses identified TRAIL pathway for osteoporotic fractures

Hip OF carries the highest morbidity and mortality. Previous studies revealed that individual genes/loci in the Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) pathway were associated with bone metabolism. This study aims to verify the potential association between hip OF and T...

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Bibliographic Details
Published in:PloS one 2011-07, Vol.6 (7), p.e21835-e21835
Main Authors: Zhang, Yin-Ping, Liu, Yao-Zhong, Guo, Yan, Liu, Xiao-Gang, Xu, Xiang-Hong, Guo, Yan-Fang, Chen, Yuan, Zhang, Feng, Pan, Feng, Zhu, Xue-Zhen, Deng, Hong-Wen
Format: Article
Language:English
Subjects:
Age
Aged
Alleles
Apoptosis
Association analysis
Biocompatibility
Biology
Biomarkers
Bone diseases
Bone turnover
Cancer
Cytokines
Data processing
Education
Engineering
Epidemiology
Family medical history
Female
Fractures
Genes
Genetic aspects
Genetic Predisposition to Disease
Genetics
Genomes
Genomics
Genotypes
Geriatrics
Health aspects
Hip
Humans
Laboratories
Life sciences
Ligands
Male
Medical research
Medicine
Metabolism
Morbidity
Mortality
Older people
Osteoporosis
Osteoporotic Fractures - genetics
Osteoprotegerin
Pathogenesis
Physiological aspects
Polymorphism, Single Nucleotide - genetics
Population
Population studies
Prevention
Public health
Retailing
Signal Transduction - genetics
Single-nucleotide polymorphism
Studies
TNF-Related Apoptosis-Inducing Ligand - genetics
TRAIL protein
Tumor necrosis factor
Tumor necrosis factor-TNF
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Summary:Hip OF carries the highest morbidity and mortality. Previous studies revealed that individual genes/loci in the Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) pathway were associated with bone metabolism. This study aims to verify the potential association between hip OF and TRAIL pathway. Using genome-wide genotype data from Affymetrix 500 K SNP arrays, we performed novel pathway-based association analyses for hip OF in 700 elderly Chinese Han subjects (350 with hip OF and 350 healthy matched controls). The TRAIL pathway achieved a significant p value (p = 0.01) for association with hip OF. Among the 38 genes in the TRAIL pathway, seven genes achieved nominally significant association with hip OF (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0021835