Adenovirus-vectored drug-vaccine duo as a rapid-response tool for conferring seamless protection against influenza

Few other diseases exert such a huge toll of suffering as influenza. We report here that intranasal (i.n.) administration of E1/E3-defective (ΔE1E3) adenovirus serotype 5 (Ad5) particles rapidly induced an anti-influenza state as a means of prophylactic therapy which persisted for several weeks in m...

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Bibliographic Details
Published in:PloS one 2011-07, Vol.6 (7), p.e22605-e22605
Main Authors: Zhang, Jianfeng, Tarbet, E Bart, Feng, Tsungwei, Shi, Zhongkai, Van Kampen, Kent R, Tang, De-chu C
Format: Article
Language:English
Subjects:
Adenoviridae - genetics
Adenoviruses
Animals
Antibodies, Viral - blood
Antiviral Agents - therapeutic use
Biology
Drug resistance
Drug therapy
Drugs
Genetic Vectors - genetics
Health Status
Hemagglutinins
Humans
Immunity
Immunoglobulins
Influenza
Influenza A Virus, H1N1 Subtype - immunology
Influenza vaccines
Influenza Vaccines - immunology
Influenza viruses
Influenza, Human - drug therapy
Influenza, Human - immunology
Influenza, Human - prevention & control
Influenza, Human - virology
Innate immunity
Lung - immunology
Lung - pathology
Lung - virology
Medicine
Mice
Optical disks
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - prevention & control
Orthomyxoviridae Infections - virology
Preventive medicine
Respiratory tract
Vaccination
Vaccines
Viruses
Weight Loss
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Summary:Few other diseases exert such a huge toll of suffering as influenza. We report here that intranasal (i.n.) administration of E1/E3-defective (ΔE1E3) adenovirus serotype 5 (Ad5) particles rapidly induced an anti-influenza state as a means of prophylactic therapy which persisted for several weeks in mice. By encoding an influenza virus (IFV) hemagglutinin (HA) HA1 domain, an Ad5-HA1 vector conferred rapid protection as a prophylactic drug followed by elicitation of sustained protective immunity as a vaccine for inducing seamless protection against influenza as a drug-vaccine duo (DVD) in a single package. Since Ad5 particles induce a complex web of host responses, which could arrest influenza by activating a specific arm of innate immunity to impede IFV growth in the airway, it is conceivable that this multi-pronged influenza DVD may escape the fate of drug resistance that impairs the current influenza drugs.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0022605