Noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo

The blood-brain barrier (BBB) is a specialized vascular system that impedes entry of all large and the vast majority of small molecules including the most potent central nervous system (CNS) disease therapeutic agents from entering from the lumen into the brain parenchyma. Microbubble-enhanced, focu...

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Bibliographic Details
Published in:PloS one 2011-07, Vol.6 (7), p.e22598-e22598
Main Authors: Marquet, Fabrice, Tung, Yao-Sheng, Teichert, Tobias, Ferrera, Vincent P, Konofagou, Elisa E
Format: Article
Language:English
Subjects:
Animals
Biology
Biomedical engineering
Blood-brain barrier
Blood-Brain Barrier - diagnostic imaging
Blood-Brain Barrier - injuries
Blood-Brain Barrier - metabolism
Brain damage
Brain injury
Brain research
Cavitation
Central nervous system
Chemical compounds
Clinical trials
Damage assessment
Disruption
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
Engineering
Feasibility Studies
Ferroelectrics
Gene therapy
Health aspects
Magnetic Resonance Imaging
Medicine
Microbubbles
Neurosciences
Parenchyma
Pharmacology
Primates
Time Factors
Ultrasonic imaging
Ultrasonics - instrumentation
Ultrasonics - methods
Ultrasonography
Ultrasound
Vascular system
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Summary:The blood-brain barrier (BBB) is a specialized vascular system that impedes entry of all large and the vast majority of small molecules including the most potent central nervous system (CNS) disease therapeutic agents from entering from the lumen into the brain parenchyma. Microbubble-enhanced, focused ultrasound (ME-FUS) has been previously shown to disrupt noninvasively, selectively, and transiently the BBB in small animals in vivo. For the first time, the feasibility of transcranial ME-FUS BBB opening in non-human primates is demonstrated with subsequent BBB recovery. Sonications were combined with two different types of microbubbles (customized 4-5 µm and Definity®). 3T MRI was used to confirm the BBB disruption and to assess brain damage.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0022598