Peritoneal cavity is dominated by IFNγ-secreting CXCR3+ Th1 cells

The chemokine receptor CXCR3, which was shown to take part in many inflammatory processes, is considered as a Th1 specific marker. Here, we show in a mouse model that CXCR3 expressing CD4(+) cells preferentially migrate to the peritoneal cavity under steady-state conditions. The peritoneal cavity mi...

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Bibliographic Details
Published in:PloS one 2011, Vol.6 (7), p.e18032-e18032
Main Authors: Zygmunt, Beata M, Groebe, Lothar, Guzman, Carlos A
Format: Article
Language:English
Subjects:
Animals
Bacteria
Biology
Bordetella bronchiseptica
CD4 antigen
Cell adhesion & migration
Cell Proliferation
Chemokines
Computer memory
CXCR3 protein
Cytokines
Experiments
Gene expression
Immunoglobulins
Immunologic Memory
Infections
Inflammation
Interferon-gamma - secretion
Interleukin 4
Leukocyte migration
Ligands
Lymphocyte Subsets - cytology
Lymphocytes
Lymphocytes T
Memory cells
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Neutralization Tests
Organ Specificity
Peritoneal Cavity - cytology
Peritoneum
Pneumonia
Receptors, CXCR3 - metabolism
Recruitment
T cell receptors
Th1 Cells - cytology
Th1 Cells - immunology
Th1 Cells - secretion
γ-Interferon
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Description
Summary:The chemokine receptor CXCR3, which was shown to take part in many inflammatory processes, is considered as a Th1 specific marker. Here, we show in a mouse model that CXCR3 expressing CD4(+) cells preferentially migrate to the peritoneal cavity under steady-state conditions. The peritoneal cavity milieu leads to an up-regulated expression of CXCR3. However, blocking of known ligands of this chemokine receptor did not alter the preferential migration. The peritoneal cavity environment also results in an increased percentage of memory cells producing cytokines. Up-regulation of IFNγ production occurs mostly in CXCR3(+) cells considered as Th1, whereas the up-regulation of IL-4 affects mostly in CXCR3(-) cells which are considered as Th2. We conclude that the peritoneal cavity does not change the Th-lineage of the cells, but that domination of this anatomic niche by Th1 cells rather results from preferential migration to this compartment.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0018032