An electronic analog of synthetic genetic networks

An electronic analog of a synthetic genetic network known as the repressilator is proposed. The repressilator is a synthetic biological clock consisting of a cyclic inhibitory network of three negative regulatory genes which produces oscillations in the expressed protein concentrations. Compared to...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2011-08, Vol.6 (8), p.e23286-e23286
Main Authors: Hellen, Edward H, Volkov, Evgenii, Kurths, Jurgen, Dana, Syamal Kumar
Format: Article
Language:English
Subjects:
Analogs
Bioengineering
Biology
Circuits
Communication
Gene Expression
Gene Regulatory Networks
Genes
Kinetics
Mathematical models
Mathematics
Models, Theoretical
Molecular biology
Numerical prediction
Oscillations
Physics
Population
Proteins
Proteolysis
Rhythm
Transistors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An electronic analog of a synthetic genetic network known as the repressilator is proposed. The repressilator is a synthetic biological clock consisting of a cyclic inhibitory network of three negative regulatory genes which produces oscillations in the expressed protein concentrations. Compared to previous circuit analogs of the repressilator, the circuit here takes into account more accurately the kinetics of gene expression, inhibition, and protein degradation. A good agreement between circuit measurements and numerical prediction is observed. The circuit allows for easy control of the kinetic parameters thereby aiding investigations of large varieties of potential dynamics.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0023286