Extracorporeal shock wave therapy reverses ischemia-related left ventricular dysfunction and remodeling: molecular-cellular and functional assessment

An optimal treatment for patients with diffuse obstructive arterial disease unsuitable for catheter-based or surgical intervention is still pending. This study tested the hypothesis that extracorporeal shock wave (ECSW) therapy may be a therapeutic alternative under such clinical situation. Myocardi...

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Bibliographic Details
Published in:PloS one 2011-09, Vol.6 (9), p.e24342-e24342
Main Authors: Fu, Morgan, Sun, Cheuk-Kwan, Lin, Yu-Chun, Wang, Ching-Jen, Wu, Chiung-Jen, Ko, Sheung-Fat, Chua, Sarah, Sheu, Jiunn-Jye, Chiang, Chiang-Hua, Shao, Pei-Lin, Leu, Steve, Yip, Hon-Kan
Format: Article
Language:English
Subjects:
Angina pectoris
Angiogenesis
Angiography
Animals
Apoptosis
Bax protein
Bcl-2 protein
Biology
Bone marrow
Bone surgery
Cardiology
Cardiomyopathy
Cardiovascular disease
Caspase
Caspase-3
Catheters
CD40 antigen
Coronary vessels
CXCR4 protein
Cytochrome
Cytochrome c
Echocardiography
Fibrosis
Gelatinase B
Health aspects
Heart
Heart attacks
High-Energy Shock Waves - therapeutic use
Hospitals
Immunofluorescence
Immunohistochemistry
Internal medicine
Ischemia
Laboratory animals
Lithotripsy
Male
Medical instruments
Medical research
Medical treatment
Medicine
Mitochondria
Mortality
mRNA
Myocardial ischemia
Nuclei
Nuclei (cytology)
Ostomy
Oxidative stress
Physicians
Pigs
Propagation
Remodeling
RNA
Shock waves
Staining
Surgery
Swine
Swine, Miniature
Therapy
Ulcers
Ultrasonic imaging
Vascular endothelial growth factor
Ventricle
Ventricular Dysfunction, Left - radiotherapy
Ventricular Remodeling - radiation effects
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Summary:An optimal treatment for patients with diffuse obstructive arterial disease unsuitable for catheter-based or surgical intervention is still pending. This study tested the hypothesis that extracorporeal shock wave (ECSW) therapy may be a therapeutic alternative under such clinical situation. Myocardial ischemia was induced in male mini-pigs through applying an ameroid constrictor over mid-left anterior descending artery (LAD). Twelve mini-pigs were equally randomized into group 1 (Constrictor over LAD only) and group 2 (Constrictor over LAD plus ECSW [800 impulses at 0.09 mJ/mm(2)] once 3 months after the procedure). Results showed that the parameters measured by echocardiography did not differ between two groups on days 0 and 90. However, echocardiography and left ventricular (LV) angiography showed higher LV ejection fraction and lower LV end-systolic dimension and volume in group 2 on day 180 (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0024342