Early lung function testing in infants with aortic arch anomalies identifies patients at risk for airway obstruction

Aortic arch anomalies (AAA) are rare cardio-vascular anomalies. Right-sided and double-sided aortic arch anomalies (RAAA, DAAA) are distinguished, both may cause airway obstructions. We studied the degree of airway obstruction in infants with AAA by neonatal lung function testing (LFT). 17 patients...

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Bibliographic Details
Published in:PloS one 2011-09, Vol.6 (9), p.e24903-e24903
Main Authors: Roehr, Charles Christoph, Wilitzki, Silke, Opgen-Rhein, Bernd, Kalache, Karim, Proquitté, Hans, Bührer, Christoph, Schmalisch, Gerd
Format: Article
Language:English
Subjects:
Airway management
Airway obstruction
Airway Obstruction - diagnosis
Airway Obstruction - etiology
Airway Obstruction - physiopathology
Anomalies
Aorta
Aorta, Thoracic - abnormalities
Aorta, Thoracic - physiopathology
Aortic arch
Aortic Arch Syndromes - complications
Aortic Arch Syndromes - physiopathology
Automation
Babies
Biology
Body weight
Breathing
Collaboration
Compression
Congenital diseases
Diagnosis
Female
Health screening
Humans
Infant
Infant, Newborn
Infants
Lung - physiopathology
Lung diseases
Lungs
Male
Medical imaging
Medical research
Medicine
Neonates
Newborn babies
Newborn infants
NMR
Nuclear magnetic resonance
Obstructions
Patients
Pediatrics
Prenatal diagnosis
Pulmonary function tests
Reproducibility of Results
Respiratory function
Respiratory Function Tests - methods
Respiratory tract
Retrospective Studies
Risk
Risk Factors
Sensitivity and Specificity
Statistical analysis
Studies
Task forces
Test procedures
Therapeutic applications
Thorax
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Summary:Aortic arch anomalies (AAA) are rare cardio-vascular anomalies. Right-sided and double-sided aortic arch anomalies (RAAA, DAAA) are distinguished, both may cause airway obstructions. We studied the degree of airway obstruction in infants with AAA by neonatal lung function testing (LFT). 17 patients (10 RAAA and 7 DAAA) with prenatal diagnosis of AAA were investigated. The median (range) post conception age at LFT was 40.3 (36.6-44.1) weeks, median body weight 3400 (2320-4665) g. Measurements included tidal breathing flow-volume loops (TBFVL), airway resistance (R(aw)) by bodyplethysmography and the maximal expiratory flow at functional residual capacity (V'(max)FRC) by rapid thoracic-abdominal compression (RTC) technique. V'(max)FRC was also expressed in Z-scores, based on published gender-, age and height-specific reference values. Abnormal lung function tests were seen in both RAAA and DAAA infants. Compared to RAAA infants, infants with DAAA had significantly more expiratory flow limitations in the TBFVL, (86% vs. 30%, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0024903